微生态制剂联合双环醇对非酒精性脂肪肝的临床疗效及对肝纤维化、血脂水平、血清炎症因子、TGF-β1的影响

Clinical effect of microecological preparation combined with bicyclol on non-alcoholic fatty liver and its effect on liver fibrosis,blood lipid levels,serum inflammatory factors,and TGF-β1

目的:探讨微生态制剂联合双环醇对非酒精性脂肪肝(NAFLD)的临床疗效及对肝纤维化、血脂、血清炎症因子、转化生长因子β1(TGF-β1)的影响。方法:选取符合要求的NAFLD患者106例,分为对照组和病例组各53例。对照组给予常规护肝和双环醇;病例组在对照组治疗的基础上给予微生态制剂双歧杆菌三联活菌。两组治疗6周,观察两组治疗后的临床疗效、肝纤维化、血清炎症因子、TGF-β1等变化。结果:病例组的总有效率高于对照组,差异有统计学意义(χ2=4.970,P=0.026)。两组治疗后ALB、HDL较前升高,ALT、AST、TBIL、LN、HA、PCⅢ、CIV、TC、TG、LDL、IL-6、TNF-a、hs-CRP、TGF-β1较前降低,同组治疗前后比较,差异具有统计学意义(P<0.05);且病例组肝功能、肝纤维化、血脂水平、血清炎性因子、TGF-β1改善优于对照组,差异有统计学意义(P<0.05)。病例组不良反应发生率低于对照组,差异无统计学意义(χ2=1.093,P=0.296)。结论:微生态制剂联合双环醇治疗NAFLD临床疗效确切,可以明显改善肝功能,降低血脂,减轻炎症刺激和肝纤维化程度,安全性较好。

Objective:To investigate the clinical effect of microecological preparation combined with bicyclol on nonalcoholic fatty liver(NAFLD)and its effect on liver fibrosis,serum inflammatory factors and transforming growth factorβ1(TGF-β1).Methods:Totally 106 patients with NAFLD were randomly divided into control group and case group with 53 cases each.The control group was given routine liver protection and bicyclol,and the case group was given Bifidobacterium triple viable probiotics based on the treatment of the control group.The two groups were treated for 6 weeks.The clinical effect,liver fibrosis,serum inflammatory factors,TGF-β1 and other changes were observed in the two groups after treatment.Results:The total effective rate of the case group was significantly higher than that of the control group,(χ2=4.970,P=0.026).After treatment,the ALB and HDL levels of the two groups of patients were higher than before.ALT,AST,and TBIL,LN,HA,PCⅢ,CIV,TC,TG,LDL,IL-6,TNF-a,hs-CRP,TGF-β1 were lower,compared with before and after treatment;and the improvement of liver function,liver fibrosis,blood lipid levels,serum inflammatory factors,and TGF-β1 in the case group was better than that in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the case group was lower than that in the control group.The difference was not statistically significant(χ2=1.093,P=0.296).Conclusion:Microecological preparations combined with bicyclol in the treatment of NAFLD have exact clinical effects,can significantly improve liver function,regulate blood lipid levels,reduce inflammation and liver fibrosis,and have good safety,which deserves further clinical research and promotion.