RNA m6A甲基化在泌尿生殖系肿瘤中的研究进展

Research progress of RNA mA methylation in urogenital tumors

RNA m6A甲基化是真核生物普遍存在的一种动态可逆的修饰,由m6A甲基转移酶、m6A去甲基化酶、m6A结合蛋白3种蛋白参与,调节RNA剪切、转运、稳定性以及翻译成蛋白质。其与多种生理过程相关,尤其与肿瘤的关系密切。但RNA m6A甲基化在泌尿生殖系肿瘤中的研究较少。因此本文就RNA m6A甲基化在肿瘤中的作用以及在泌尿生殖系中研究进展作一综述。

RNA m6A methylation is a kind of dynamic reversible modification commonly existing in eukaryotes.It is involved in three proteins,namely m6A methyltransferase,m6A demethylase and m6A binding protein,which regulate RNA shearing,transport,stability and translation into proteins.It is closely related to many physiological processes,especially in tumors.However,there are few studies on RNA m6A methylation in urogenital tumors.Therefore,this article reviews the role of RNA m6A methylation in tumors and its research progress in the urogenital system.