新型杀虫剂broflanilide的合成及其杀虫活性测定

Synthesis and Insecticidal Activity of Broflanilide

总结并改进新型杀虫剂broflanilide合成方法,并对其进行温室杀虫活性测试。以2-氟-3-硝基苯甲酸和2-(三氟甲基)苯胺为原料,经7步反应合成目标化合物broflanilide,目标化合物结构经1H NMR、ESI-MS确证,反应总收率为29.46%。改进后的反应路线条件温和,操作简便,易于制备,原料价格低廉,经济可行性较高。温室杀虫活性测试结果表明,在1.25 mg/L的低质量浓度下,Broflanilide对小菜蛾(Plutella xylostella)、黏虫(Mythimna seperata)的杀虫活性仍可达到100%,优于对照药剂氯虫苯甲酰胺。

The synthesis method of Broflanilide was summarized and improved,and its insecticidal activity in greenhouse was tested.Broflanilide was synthesized from 2-fluoro-3-nitrobenzoic acid and 2-(trifluoromethyl)aniline in 7 steps.The structure of the target compound was confirmed by 1H NMR and ESI-MS,and the total yield was 29.46%.The improved reaction route has mild conditions,simple operation,easy preparation,low price of raw materials and high economic feasibility.The results of greenhouse insecticidal activity test showed that Broflanilide could still achieve 100%insecticidal activity against Plutella xylostella and Mythimna seperata low mass concentration of 1.25 mg/L,which was better than the control agent Chlorantraniliprole.