肺癌患者化疗后细菌感染患者C反应蛋白、降钙素原、中性粒细胞及NLR水平研究

Study on the levels of C-reactive protein,procalcitonin,neutrophil count and NLR in patients with bacterial infection after chemotherapy

目的探讨C反应蛋白(CRP)、降钙素原(PCT)、中性粒细胞计数(NC)及中性粒细胞/淋巴细胞比值(NLR)在肺癌患者化疗后合并细菌感染早期诊断中的意义。方法收集本院肿瘤科2019年1月—2019年12月肺癌化疗后合并细菌感染患者78例,肺癌化疗后未感染患者64例,同期健康体检人群39例,采用固相免疫色谱法和速率散射比浊法测定血清中的PCT及CRP的含量,采用mindray cal8000血细胞分析仪进行血细胞分类计数检查,计算N及NLR。结果化疗后感染组CRP、PCT、NC及NLR均高于化疗未感染组及健康对照组,差异均有统计学意义(P<0.01);化疗未感染组与健康对照组CRP、PCT、NC及NLR差异有统计学意义(P<0.01)。CRP、PCT、NC及NLR联合使用时,其灵敏度为97.507%,而特异度升高为97.15%。细菌感染患者治疗前的PCT、CRP、NC及NLR与治疗后相比较差异有统计学意义(P<0.05),治疗后低于治疗前。结论PCT、CRP、NC及NLR联合检测能够提高对肺癌患者化疗后合并细菌感染早期诊断的敏感度和特异度。

Objective To explore the significance of C-reactive protein(CRP),procalcitonin(PCT),neutrophil count(NC)and neutrophil/lymphocyte ratio(NLR)in the early diagnosis of bacterial infection in lung cancer patients after chemotherapy.Methods From January 2019 to December 2019,78 cases of lung cancer patients with bacterial infection after chemotherapy,64 cases of uninfected patients after chemotherapy and 39 cases of healthy people in the same period were collected.the contents of PCT and CRP in serum were detected by solid phase immunosorbent assay and rate nephelometry.The NC and NLR were classified and counted by mindray cal8000 hematology analyzer.Results After chemotherapy,CRP,PCT,NC and NLR in the infected group were higher than those in the uninfected group and the healthy control group(P<0.01),while CRP,PCT,NC and NLR in the uninfected group were higher than those in the healthy control group(P<0.01).When CRP,PCT,NC and NLR were used together,the sensitivity was 97.507%,while the specificity increased by 97.15%.The PCT,CRP,NC and NLR of patients with bacterial infection before treatment were lower than those after treatment(P<0.05).Conclusion PCT,CRP,NC and NLR may improve the sensitivity and specificity of early diagnosis of bacterial infection in patients with lung cancer after chemotherapy.