摘要
本文的目的是开发非布索坦新的固态化学形式,并期望能进一步改善非布索坦的溶解特性。本文利用溶剂辅助研磨法成功制备了两种非布索坦-烟酸系列新共晶,并通过红外、粉末X射线衍射和差示扫描量热法对其进行了理化性质表征。与非布索坦Z晶型相比较,非布索坦-异烟酸共晶表现出更高的热稳定性。
The purpose of this paper is to develop the new solid-state chemical form of febuxostat,and to improve the solubility of febuxostat.In this paper,two new cocrystals of febuxostat were prepared by solvent-assisted grinding,and their physical and chemical properties were characterized by infrared spectroscopy,powder X-ray diffraction and differential scanning calorimetry.Compared with febuxostat(Polymorph Z),febuxostat-isonicotinic acid cocrystal showed higher thermal stability.
作者
张宪瑞
高蕾
Zhang Xianrui;Gao Lei(School of Chemical Engineering and Resource Recycling,Wuzhou University,Wuzhou 543000,China)
出处
《广东化工》
CAS
2020年第11期27-28,共2页
Guangdong Chemical Industry
基金
广西自然科学基金项目(2018GXNSFBA281167)资助
广西高校中青年教师科研基础能力提升项目(2019KY0700和2020KY17020)资助。
关键词
非布索坦
共晶
烟酸
△pKa
febuxostat
cocrystal
nicotinic acid
△pKa
