苯巴比妥联合地西泮治疗小儿惊厥的临床分析

Clinical Analysis of Phenobarbital Combined with Diazepam in the Treatment of Infantile Convulsion

目的分析并研究采用苯巴比妥联合地西泮对小儿惊厥进行治疗的效果。方法选择我院在2017年3月至2018年10月收治的小儿惊厥患儿54例作为研究对象,将所有患儿按照随机方法分为常规治疗组和联合治疗组,平均每组患儿均为27例。常规治疗组患儿选择采用苯巴比妥进行治疗,联合治疗组选择采用苯巴比妥联合地西泮治疗,对两组患者治疗的效果进行评价。结果常规治疗组的治疗总有效率为71.43%(20/28),联合治疗组为89.29%(25/28),P<0.05,差异存在统计学意义;常规治疗组的不良反应发生率为14.29%(4/28),联合治疗组为17.86%(5/28),P<0.05,差异存在统计学意义;对两组患儿经过不同治疗以后的退热时间、惊觉消退时间和满意度评分进行比较,本文的联合治疗组也明显优于常规治疗组,P<0.05,差异存在统计学意义。结论临床对小儿惊厥治疗的过程中选择采用苯巴比妥联合地西泮进行治疗,可有效的帮助患儿提高治疗总有效率,而且具有一定的安全性,大大的帮助患者改善的临床症状,促进患儿病情的恢复,值得推广应用。

Objective To analyze and study the effi cacy of phenobarbital combined with diazepam in the treatment of pediatric convulsion.Methods A total of 54 children with pediatric convulsion admitted to our hospital from March 2017 to October 2018 were selected as subjects.All children were randomly divided into the conventional treatment group and the combined treatment group,with an average of 27 children in each group.Children in the conventional treatment group were treated with phenobarbital,while those in the combined treatment group were treated with phenobarbital combined with diazepam.The therapeutic effects of the two groups were evaluated.Results The total effective rate of the conventional treatment group was 71.43%(20/28),and that of the combined treatment group was 89.29%(25/28),P<0.05,the difference was statistically signifi cant.The incidence of adverse reactions was 14.29%(4/28)in the conventional treatment group and 17.86%(5/28)in the combined treatment group,P<0.05,indicating a statistically signifi cant difference.After the two groups of children after different treatment of antipyretic time,alarm subsided time and satisfaction score were compared,the combined treatment group in this paper was also signifi cantly better than the conventional treatment group,P<0.05,the difference was statistically signifi cant.Conclusion The combination of phenobarbital and diazepam in the clinical treatment of pediatric convulsion can effectively help children improve the total effective rate of treatment,and has certain safety,greatly helping patients to improve the clinical symptoms and promote the recovery of children's conditions,which is worthy of promotion and application.