肿瘤标志物CA19-9、CA242、CEA和CA125联合检测在胰腺癌诊断中的意义

Significance of Combined Detection of Tumor Markers CA19-9,CA242,CEA and CA125 in the Diagnosis of Pancreatic Cancer

目的探讨肿瘤标志物CA19-9(糖抗原19-9)、CA242(糖抗原242)、CEA(癌胚抗原)和CA125(糖抗原125)联合检测在胰腺癌诊断中的意义。方法选择本院于2016年6月至2018年6月收治的胰腺癌患者42例作为观察组研究资料,另选择同时间段本院收治的健康体检者42例作为对照组,均行肿瘤标志物CA19-9、CA242、CEA和CA125检测,比较两组肿瘤标志物各指标,比较观察组不同分期患者各指标水平。结果观察组肿瘤标志物各指标CA19-9、CA242、CEA和CA125与对照组比较均明显更高,P<0.05;Ⅳ期肿瘤标志物各指标水平CA19-9、CA242、CEA和CA125显著高于Ⅰ期、Ⅱ~Ⅲ期,Ⅱ~Ⅲ期肿瘤标志物各指标水平显著高于Ⅰ期,P<0.05。结论加强肿瘤标志物CA19-9、CA242、CEA和CA125检测对诊断胰腺癌具有较高价值,尤其各指标联合检测可进一步提高检出率,应用价值较高。

Objective To investigate the signifi cance of combined detection of tumor markers CA19-9(sugar antigen 19-9),CA242(glucose antigen 242),CEA(carcinoembryonic antigen)and CA125(sugar antigen 125)in the diagnosis of pancreatic cancer.Methods A total of 42 patients with pancreatic cancer admitted to our hospital from June 2016 to June 2018 were enrolled as the observation group.Another 42 healthy subjects admitted to our hospital at the same time were selected as the control group.The markers CA19-9,CA242,CEA and CA125 were detected,and the indexes of the tumor markers in the two groups were compared,and the levels of the indicators in the different stages of the observation group were compared.Results The CA12-9,CA242,CEA and CA125 of the tumor markers in the observation group were signifi cantly higher than those in the control group,P<0.05.The levels of the tumor markers in theⅣstage were signifi cantly higher than those of CA19-9,CA242,CEA and CA125.In stage I and stageⅡ-Ⅲ,the levels of tumor markers in stageⅡ-Ⅲwere signifi cantly higher than those in stage I,P<0.05.Conclusion Strengthening the detection of tumor markers CA19-9,CA242,CEA and CA125 has a high value for the diagnosis of pancreatic cancer.In particular,the combined detection of each index can further improve the detection rate and has a higher application value.