基于2018版《国家基本药物目录》中治疗心血管疾病的中成药科学知识图谱可视化分析

Visualization analysis of scientific knowledge maps of Chinese patent medicine for treating cardiovascular diseases based on the 2018 edition of National Essential Drugs List

[目的]展示近6年间《国家基本药物目录》中共35种中成药在治疗心血管疾病方面的研究和趋势,并分析2018版《国家基本药物目录》中3种新增中成药在治疗心血管疾病方面的研究动向。[方法]文章以中国知网(CNKI)2013年5月1日—2018年11月1日期间检索35种中成药研究发表的相关论文为研究对象,采用文献计量学的方法,运用CiteSpace可视化分析软件对数据进行计量分析,分别绘制作者、机构合作网络分析图谱、关键词共现和聚类图谱,以及时间线视图和时区视图。[结果]通过检索共获得13806篇文献,年平均发文量在2300篇左右。中成药丹参注射液的相关研究文献最多,文献被引用频次也最高;国家自然科学基金在科学基金资助项目中支持力度最大,受资助最多的中成药是参麦注射液,其次是丹参注射液;高产核心作者以魏聪、赵步长为主;天津中医药大学在机构分析中发文量最高。研究热点主要体现在对冠心病的治疗和系统评价的临床证据研究。[结论]综合分析表明,对中成药治疗心血管疾病的研究越来越被国家和相关研究人员所重视,预测中成药个性治疗可能成为未来研究的热点话题。

[Objective]We demonstrated the research status and development trend of the 35 kinds of chinese patent medicines treating cardiovascular diseases in the national essential medicines in the past six years.Furthermore,we also analyze the research trend of three new Chinese patent medicines in the treatment of cardiovascular diseases in the 2018 essential medicines catalogue.[Methods]We proposed a research on the literature analysis,relating to the 35 kinds of chinese patent medicine,ranging from 1 May 2013 to 1 November 2018 in China Knowledge Network(CNKI)database by the bibliometrics method.The econometric analysis was carried out using the CiteSpace visual analysis software,drawed author,institutional cooperation network analysis map,keywords co-occurrence and clustering map,a Timeline view and a Timezone view,respectively.[Results]A total of 13,806 articles were obtained through the database search with an average annual publication volume of about 2,300.Among of them,Danshen injection,a Chinese patent medicine,had the most relevant research literature and the highest citation frequency.Shenmai injection was greatly supported from the National Natural Science Foundation of China supports in science funded projects followed by Danshen injection.The core author of high production was mainly WEI Cong and ZHAO Buchang.Tianjin University of Traditional Chinese Medicine had the highest number of documents in institutional analysis.Research hotspots were mainly reflected in the treatment of coronary heart disease and systematic evaluation of clinical evidence.[Conclusion]The comprehensive analysis showed that the research on the treatment of cardiovascular diseases by Chinese patent medicines have substantial research attention from the state and relevant researchers due to their impressively high efficacy.The personalized treatment of proprietary Chinese medicines will be a hot topic in the near future research.