阿奇霉素联合盐酸氨溴索对支原体肺炎患儿肺功能及细胞因子的影响

Effects of azithromycin combined with ambroxol hydrochloride on pulmonary function and cytokines in children with mycoplasma pneumonia

目的探讨阿奇霉素联合盐酸氨溴索对支原体肺炎患儿肺功能及细胞因子的影响。方法选取2018年2月-2019年2月我院收治的支原体肺炎患儿106例,按照随机数字表法分成对照组和观察组,两组均为53例,对照组给予阿奇霉素治疗,观察组接受阿奇霉素联合盐酸氨溴索治疗,比较两组肺功能、细胞因子。结果治疗后,观察组最大通气量(MVV)(49.57±2.84)L/min、第1秒用力呼气容积/用力肺活量(FEV1/FVC)(72.19±4.08)%、最大呼气流量(PEF)水平(2.92±0.18)L/s,高于对照组(46.78±3.15)L/min、(69.45±3.25)%、(2.64±0.25)L/s,白介素-17(IL-17)(19.82±3.54)pg/mL、白介素-18(IL-18)(104.35±17.53)pg/mL、γ干扰素(IFN-γ)(26.58±11.86)pg/mL,低于对照组(24.57±6.47)pg/mL、(121.19±15.76)pg/mL、(36.59±12.93)pg/mL,差异有统计学意义(P<0.05)。结论阿奇霉素结合盐酸氨溴索治疗,可有效改善支原体肺炎患儿的肺功能,降低细胞因子水平,利于患儿康复。

Objective To investigate the effect of azithromycin combined with ambroxol hydrochloride on pulmonary function and cytokines in children with mycoplasma pneumonia.Methods A total of 106 children with mycoplasma pneumonia treated in a hospital from February 2018 to February 2019 were randomly divided into a control group(n=53)and a trial group(n=53).The control group was treated with azithromycin and the trial group was treated with azithromycin combined with ambroxol hydrochloride.The lung function and cytokines were investigated and compared between the two groups.Results After the treatment,in the trial group,the average maximum ventilation volume(MVV)was(49.57±2.84)L/min,the forced exhalation volume/forced lung activity in the first second(FEV1/FVC)was(72.19±4.08)%,and the maximum breath flow(PEF)level was(2.92±0.18)L/s,which were higher than those in the control group[(46.78±3.15)L/min,(69.45±3.25)%,and(2.64±0.25)L/s];in the trial group,IL-17 was(19.82±3.54)pg/mL,IL-18 was(104.35±17.53)pg/mL,and interferon gamma(IFN-γ)was(26.58±11.86)pg/mL,which were lower than those in the control group[(24.57±6.47)pg/mL,(121.19±15.76)pg/mL,and(36.59±12.93)pg/mL],and there were significant differences between the two groups(all P<0.05).Conclusion Azithromycin combined with ambroxol hydrochloride can effectively improve the pulmonary function of children with mycoplasma pneumonia,reduce the level of cytokines,and is beneficial for the rehabilitation of children with mycoplasma pneumonia.