牙周组织再生术配合正畸治疗对糖尿病伴慢性牙周炎患者血清sICAM-1及氧化应激水平的影响

Effect of periodontal tissue regeneration combined with orthodontic treatment on serum levels of sICAM-1 and oxidative stress in patients with diabetes mellitus and chronic periodontitis

目的研究牙周组织再生术配合正畸治疗对糖尿病伴慢性牙周炎患者血清可溶性细胞间黏附分子-1(sICAM-1)及氧化应激水平的影响。方法 88例糖尿病伴慢性牙周炎患者依据患者和家属治疗意愿将患者分为对照组(43例)和观察组(45例),两组均予以牙周基础治疗,对照组在此基础上采用牙周组织再生术治疗,观察组在此基础上采用牙周组织再生术联合正畸治疗,比较两组临床疗效,治疗前后牙周状态,血清sICAM-1和氧化应激水平,主观满意度和不良反应发生情况。结果治疗结束后3个月,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗结束后3个月,两组牙周状态指标均较治疗前下降,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗结束后3个月,两组血清sICAM-1、丙二醛(MDA)、活性氧(ROS)均较治疗前下降,观察组低于对照组,超氧化物歧化酶(SOD)均上升,观察组高于对照组,差异有统计学意义(P<0.05)。观察组咀嚼功能、口腔清洁、牙龈健康状况和整体美观满意度均高对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论牙周组织再生术配合正畸治疗能够改善糖尿病伴慢性牙周炎患者牙周组织状态,降低血清sICAM-1水平,调节氧化应激反应。

Objective To study the effect of periodontal tissue regeneration combined with orthodontic treatment on serum levels of soluble intercellular adhesion molecule-1(sICAM-1)and oxidative stress in diabetes patients with chronic periodontitis.Methods 88 diabetic patients with chronic periodontitis were divided into control group(43 cases)and observation group(45 cases)according to the treatment wishes of patients and their families.Both groups were given periodontal basic treatment.The control group was treated with periodontal tissue regeneration on this basis.The observation group was treated with periodontal tissue regeneration combined with orthodontic treatment on this basis.Then clinical efficacy,periodontal status,serum levels of sICAM-1 and oxidative stress before and after treatment,subjective satisfaction and adverse reactions were compared between the two groups.Results After 3 months treatment,the total effective rate of the observation group was higher than that of the control group,there were statistical significantly differences(P<0.05).The periodontal status indexes of the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).The serum sICAM-1,malondialdehyde(MDA)and reactive oxygen species(ROS)in the two groups decreased compared with those before treatment.the observation group was lower than the control group,and superoxide dismutase(SOD)increased of the observation group was higher than the control group(P<0.05).The masticatory function,oral cleaning,gingival health and overall aesthetic satisfaction of the observation group were all higher than those of the control group(P<0.05).There were no statistical significantly differences in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Periodontal tissue regeneration combined with orthodontic treatment can improve periodontal tissue status of diabetes patients with chronic periodontitis,reduce serum sICAM-1 level and regulate oxidative stress response.