临床药师参与1例头孢他啶致抗生素脑病患者治疗药物监测

Therapeutic Drug Monitoring in a Antibiotic Encepha-lopathy Patient induced by Ceftazidime Involved by Clinical Pharmacists

目的:探究治疗药物监测(TDM)在诊治及预防头孢他啶致抗生素脑病的作用。方法:临床药师从分析头孢他啶致抗生素脑病发生的原因和机制,通过对患者TDM透析前后的血药浓度,评价患者症状的改善和血药浓度的变化间关系;佐证1例老年肾衰竭患者头孢他啶致抗生素脑病发生原因。结果:治疗药物浓度监测可协助临床诊治头孢他啶所致抗生素脑病。结论:治疗药物浓度监测对诊治头孢他啶致抗生素脑病的临床可操作性强,在临床治疗中通过TDM以预防抗生素脑病的发生。

Objective: To explore the role of therapeutic drug monitoring(TDM) in the diagnosis and treatment of antibiotic encephalopathy patients induced by ceftazidime involved by clinical pharmacists. Methods: The causes and mechanisms of antibiotic encephalopathy induced by ceftazidime were analyzed by clinical pharmacists, and the relationship between the improvement of symptoms and the change of blood drug concentration was evaluated by analyzing the blood drug concentration of patients before and after TDM dialysis. The cause of antibiotic encephalopathy induced by ceftazidime in an elderly patient with renal failure was evaluated. Results: The TDM is effective in clinical diagnosis and treatment of antibiotic encephalopathy caused by ceftazidime. Conclusion: Therapeutic drug concentration monitoring and treatment of antibiotic encephalopathy is clinically operability and worthy of popularization and application. It is more important to prevent the occurrence of antibiotic encephalopathy through TDM.