摘要
2019年12月以来在国内外相继出现新型冠状病毒肺炎(COVID-19)病例。氯喹作为一种经典的抗疟药物,因体外试验和临床观察提示具有抗新冠病毒(SARS-CoV-2)活性而成为目前研究的热点。本文就氯喹抗病毒研究现状、药代动力学、临床应用等信息作一概述,以期为其后续抗新冠病毒作用的开发及临床合理应用提供参考。
Cases of corona virus disease 2019(COVID-19)have emerged successively at home and abroad since December 2019.As a classical antimalarial drug,chloroquine has become the focus of current research because of its anti-SARS-CoV-2 activity suggested by in vitro tests and clinical observations.In this paper,the current situation,kinetics and clinical application of chloroquine antiviral research are summarized in order to provide a reference for the development and clinical rational application of its subsequent anti-coronavirus effect.
作者
董杰
奚鑫
杜倩
李文军
陈诚
黄贵丽
刘松青
DONG Jie;XI Xin;DU Qian;LI Wen-jun;CHEN Cheng;HUANG Gui-li;LIU Song-qing(Department of Pharmacy,The Third Affiliated Hospital of Chongqing Medical University(Gener Hospital),Chongqing 401120)
出处
《中国医院药学杂志》
CAS
北大核心
2020年第7期738-742,共5页
Chinese Journal of Hospital Pharmacy
