铝诱导神经细胞程序性死亡的研究进展

Recent advance in aluminum induced programmed death of neural cells

铝可引起神经细胞死亡,产生神经毒性并最终导致机体学习及认知功能障碍。在多细胞生物体内,程序性细胞死亡(PCD)作为细胞的一种基本生物学现象,在去除不需要或异常细胞的过程中起着重要的作用。这一过程调控异常与神经退行性病变密切相关。本综述总结铝对神经细胞凋亡、自噬及程序性坏死等PCD的影响,以期为神经退行性病变发生机制的探讨提供一定的线索。

Aluminium causes nerve cell death,neurotoxicity and eventually learning and cognitive impairment.In multicellular organisms,programmed cell death(PCD),as a basic biological phenomenon of cells,plays an important role in removing unnecessary or abnormal cells.Abnormal regulation of this process is closely related to neurodegenerative diseases.In this paper,the effects of aluminum on PCD,especially neuronal apoptosis,autophagy and programmed necrosis,are summarized to provide some clues for the pathogenesis of neurodegenerative diseases.