碳酸银催化N-氟代二苯磺酰亚胺与丙炔酸衍生物的氢胺化反应

Hydroamination of Propiolic Derivatives with N-Fluorobenzene-sulfonimide Catalyzed by Silver Carbonate

N-氟代二苯磺酰亚胺(NFSI)的胺化反应已成为制备胺类化合物的重要方法,但利用它制备N-烯基磺酰亚胺的方法不多.在磷酸氢二钠存在下,碳酸银和1,10-菲啰啉衍生物共同催化NFSI与丙炔酸酯或丙炔酰胺发生氢胺化反应,高选择性地生成顺式N-烯基二苯磺酰亚胺类化合物,产率为35%~71%.

Amination using N-fluorobenzenesulfonimide(NFSI)as nitrogen source has become an important route to prepare amines.However,there are few methods to prepare N-vinyl sulfonimides using NFSI as nitrogen source.In the presence of Na2HPO4,the hydroamination of propiolates or propiolamides with N-fluorobenzenesulfonimide(NFSI)was realized,where Ag2CO3 and 1,10-phenanthroline derivatives were added as catalysts.It leads to N-vinyldibenzenesulfonimides in high selectivity of Z isomers in the yields of 35%~71%.