室温条件下“一锅多组分”脯氨酸催化合成N,O-缩醛化合物

One-Pot Multi-component Synthesis of N,O-Acetal Compounds Catalyzed by D-Proline at Room Temperature

以芳香醛、脲和醇为原料,过量的醇为溶剂,D-脯氨酸为催化剂,开发了一种简单的多组分一锅法合成N,O-缩醛化合物的方法.在室温下反应30 h后,以良好的收率合成了一系列N,O-缩醛化合物.

In this paper,a convenient method for multi-component one-pot synthesis of N,O-acetal compounds was developed,using aromatic aldehyde,urea and alcohol as materials,alcohol also as solvent and D-proline as catalyst.A series of N,O-acetal compounds were synthesized in good yields after reacting for 30 h at room temperature.