诊断儿童药物性肝损伤应重视除外遗传代谢性肝病

Attention is paid to exclusion of genetic-metabolic liver disease in diagnosis of childhood drug-induced liver injury

药物性肝损伤是儿童非感染性肝病中的常见病,但缺乏特异性的诊断方法。遗传代谢性肝病属于罕见病,社会认知度低,需要特殊检查才能确诊。两类疾病临床表现类似,复杂多样,易将遗传代谢性肝病误诊为药物性肝损伤。临床上需提高认识,在诊断药物性肝损伤中注意除外遗传代谢性肝病,以免误诊。

Drug-induced liver injury(DILI)is a common disease in children with non-infectious liver di-seases,but there is no specific diagnostic method.Genetic-metabolic liver disease is a rare disease with low social recognition and requiring special examination to be diagnosed.The clinical manifestations of the 2 diseases are similar and complex,so it is easy to misdiagnose genetic-metabolic liver disease as DILI.In clinical practice,it is necessary to raise the awareness of excluding genetic-metabolic liver diseases in the diagnosis of DILI,so as to avoid misdiagnosis.