人乳低聚糖对婴幼儿免疫的作用

Effects of human milk oligosaccharides on infant immunity

人乳低聚糖是一类复合糖,由单糖通过糖苷键连接而成,其有助于婴幼儿免疫系统的发展。人乳低聚糖的一小部分被吸收至体循环,大部分达到结肠。人乳低聚糖除在肠腔和肠粘膜表面,可在全身多个部位发挥免疫功能。本文综述了在婴幼儿期人乳低聚糖与肠道菌群的相互作用,介导的免疫调节,对病原体和过敏反应的抑制。

Human lactooligosaccharides(HMOs) are a kind of complex sugars linked by monosaccharides through glycoside bonds,which contribute to the development of infant immune system.A small part of HMOs is absorbed into the systemic circulation,most of which reach the colon.Except for the surface of intestinal cavity and intestinal mucosa,HMOs can exert immune function in many parts of the body.This article reviews the interaction between HMOs and intestinal flora in infancy,mediation of immunoregulation,and inhibition of pathogen as well as allergic reaction.