卒中后构音障碍随机对照试验结局指标的系统评价

Outcomes reported in clinical trials of post-stroke dysarthria:a systematic review

目的系统评价卒中后构音障碍随机对照试验选用的结局指标现状,为构建卒中后构音障碍临床研究核心指标集提供参考。方法计算机检索PubMed、The Cochrane Library、EMbase、CNKI、Sinomed、WanFang Data和VIP数据库,搜集有关卒中后构音障碍治疗的随机对照试验(RCT),检索时限均从建库至2019年12月6日。由2名研究者独立筛选文献、提取资料后,采用定性分析的方法描述纳入研究的结局指标情况。结果共纳入112个RCT,涉及39种结局指标(分为疗效评价指标和安全性指标)。定性分析结果显示:当前使用最多的是Frenchay构音障碍评价量表、中国康复中心制定的构音障碍检查表、语言治疗师或临床医生的评估和GRBAS分级4种言语功能评价方法。结论当前证据表明,尚无统一的卒中后构音障碍的结局指标。建议完善相关评价量表以提高卒中后构音障碍临床试验的研究质量。

Objective To systematically review the outcomes reported in clinical trials of post-stroke dysarthria.Methods PubMed,The Cochrane Library,EMbase,CNKI,Sinomed,WanFang Data and VIP databases were electronically searched to collect randomized controlled trials(RCTs)of post-stroke dysarthria from inception to December 6 th,2019.Two reviewers independently screened literature,extracted data and analyzed outcomes using qualitative method.Result A total of 112 RCTs involving 39 outcomes(therapeutic effect assessment outcomes and safety outcomes)were included.The top 4 outcomes were the Frenchay dysarthria assessment scale,the dysarthria examination method developed by the Chinese rehabilitation center,the evaluation of the speech therapists or clinicians and GRBAS.Conclusions Current evidence shows that there is no acceptable outcomes for post-stroke dysarthria.It is recommended to improve the suitable assessment scale for Chinese to improve quality of studies on post-strohe dysarthria.