摘要
结核病(TB)是世界范围内严重危害人类健康的传染致死性疾病。异烟肼(INH)是TB治疗的重要一线药物,但其可引发肝损伤甚至肝衰竭的严重药物不良反应。目前,研究者认为INH的代谢产物、氧化应激反应失衡及免疫反应紊乱是INH致肝损伤的重要原因,相关基因多态性与INH致肝损伤密切相关。现就INH代谢酶、氧化应激反应及免疫反应相关基因的多态性与INH致肝损伤的相关性进行阐述,旨在提高对INH致肝损伤的认识,探讨其防治新方向。
Tuberculosis(TB)is an infectious fatal disease that seriously endangers human health worldwide.Isoniazid(INH)is an important first-line drug for TB,but it can cause serious adverse drug reactions,such as liver injury and even liver failure.At present,it is believed that metabolites of INH,imbalance of oxidative stress responses and immune response disorders are major causes of INH induced liver injury.In addition,involved genes and gene polymorphisms are susceptible to liver injury caused by INH.In this paper,the association of INH induced liver injury with the polymorphisms of genes related to INH metabolizing enzymes,as well as oxidative stress and immune responses are summarized to improve the understanding of INH induced liver injury and provide novel directions for its prevention and treatment.
作者
綦辉
申晨
李颖佳
申阿东
Qi Hui;Shen Chen;Li Yingjia;Shen Adong(Beijing Key Laboratory of Pediatric Respiratory Infection Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,National Key Discipline of Pediatrics(Capital Medical University),Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Department of Infectious Disease,Children′s Hospital of Hebei Pro-vince,Shijiazhuang 050010,China)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2020年第10期762-766,共5页
Chinese Journal of Applied Clinical Pediatrics
基金
国家自然科学基金(81571950,81871617,81441067)。
关键词
异烟肼致肝损伤
基因多态性
药物代谢酶
氧化应激反应
免疫反应
Isoniazid induced liver injury
Gene polymorphism
Drug metabolizing enzyme
Oxidative stress response
Immune response
