氟喹诺酮类药物在儿科呼吸系统感染性疾病中的应用

Application of Fluoroquinolones in respiratory infectious diseases in children

出于安全性的考虑,喹诺酮类药物在儿童中的应用比较谨慎。目前大多数的观点认为儿童不应禁用喹诺酮类药物。在临床实际应用中,在充分评估风险和获益的情况下,针对重症感染、耐多药病原菌感染等可酌情使用。因此,现就氟喹诺酮类抗菌药物在儿科重症、耐药呼吸系统感染性疾病治疗中的应用、对关节和软骨的损害及安全性分析、药代动力学研究、在儿童中的耐药情况进行阐述,以期为儿童重症和耐药感染性疾病的治疗提供参考。

For safety reasons,Fluoroquinolones should be used with caution in children.The current consensus is that quinolones should not be banned in children.In clinical practice,under the condition of fully evaluating the risk and benefit,it can be used as appropriate for severe infection and multi-drug resistant pathogen infection.Therefore,this paper summarizes the application of Fluoroquinolones in the treatment of severe and drug-resistant respiratory infectious diseases,safety analysis and damages of joints and cartilages,pharmacokinetic studies and drug resistance in children.The paper aims to provide a reference for the treatment of severe and drug-resistant infectious diseases in children.