帕拉米韦氯化钠注射液治疗儿童流行性感冒的疗效观察

Efficacy of palamivir sodium chloride injection for the treatment of influenza of children

目的探讨帕拉米韦氯化钠注射液治疗儿童流行性感冒的疗效及安全性,为临床安全用药提供依据。方法选取2017年1月-2018年10月涿州市医院收治的流行性感冒患儿240例,按随机数字表法将其分为观察组(n=120)和对照组(n=120)。对照组给予磷酸奥司他韦颗粒口服治疗,观察组给予帕拉米韦氯化钠注射液静脉滴注(10mg/kg,1次/d),观察2组的疗效。结果观察组治疗后的体温恢复正常时间、咳嗽缓解时间、鼻卡他/鼻塞缓解时间、咽喉痛缓解时间及症状完全缓解时间均显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗后的总有效率明显高于对照组(97.5%vs 85.8%,P<0.05)。观察组与对照组治疗后不良反应发生率比较(14.2%vs 9.2%,P>0.05),差异无统计学意义。结论采用帕拉米韦氯化钠治疗儿童流行性感冒的效果较好,能更快地改善发热和流感症状,且不增加不良反应。

Objective To explore the efficacy and safety of palamivir sodium chloride injection for the treatment of influenza in children.Methods A total of 240children with influenza admitted to Zhuozhou Hospital in Hebei province of China from January 2017to October 2018were divided into observation group(n=120)and control group(n=120)based on the random number table method.The control group was treated with oseltamivir phosphate granules,while the observation group was treated with palamivir sodium chloride injection.The efficacy and safety of the two groups were observed.Results The time of normal temperature recovery,cough relief,nasal catarrh/nasal congestion relief,throat pain relief and symptom complete relief in the observation group after treatment were significantly lower than those in the control group(P<0.05).The total effective rate of the observation group after treatment was significantly higher than that of the control group(97.5%vs 85.8%,P<0.05).There was no statistically significant difference in the incidence of adverse reactions after treatment between the two groups(14.2%vs 9.2%,P>0.05).Conclusions Paramivir sodium chloride is a better treatment for childhood influenza to improve fever and flu symptoms more quickly without increasing adverse reactions.