齐拉西酮与阿立哌唑对首发精神分裂症患者精神症状及血脂的影响分析

Analysis of the effects of ziprasidone and aripiprazole on mental symptoms and blood lipids in patients with first episode schizophrenia

目的:探讨齐拉西酮与阿立哌唑对首发精神分裂症患者精神症状及血脂的影响。方法:回顾性分析首发精神分裂症患者112例,根据不同用药分为齐拉西酮组和阿立哌唑组,采取双色球随机分组方法,每组56例。2组分别使用齐拉西酮和阿立哌唑治疗,治疗3个月后比较2组治疗前后精神症状及血脂情况。结果:2组治疗前后阳性得分、阴性得分、一般精神病理得分、PANSS总分比较,差异无统计学意义(P>0.05);治疗后齐拉西酮组阳性量表[(15.82±3.67)vs(19.91±5.84)分]、阴性量表[(15.58±4.45)vs(19.21±6.53)分]、一般精神病理[(36.39±7.75)vs(48.11±9.35)分]、PANSS[(67.79±15.87)vs(87.23±21.72)分]评分低于治疗前,阿立哌唑组阳性量表[(16.16±3.80)vs(19.90±5.86)分]、阴性量表[(15.49±5.16)vs(19.20±6.55)分]、一般精神病理[(35.65±7.42)vs(48.10±9.34)分]、PANSS[(67.30±16.38)vs(87.20±21.75)分]评分低于治疗前,差异均有统计学意义(P<0.05)。2组治疗前后TC、TG、LDL-C、HDL-C比较差异无统计学意义(P>0.05),2组治疗后组内比较差异无统计学意义(P>0.05)。结论:在首发精神分裂症患者治疗中使用齐拉西酮与阿立哌唑均可显著改善精神症状,2种药物疗效无显著差异,且对血脂均无明显影响。

Objective:To study the effects of ziprasidone and aripiprazole on psychiatric symptoms and blood lipid in patients with first-episode schizophrenia.Methods:A total of 112 patients with first-episode schizophrenia admitted were selected.According to different drugs,they were divided into ziprasidone group and aripiprazole group.The double chromosphere was used to randomly divide the patients in two groups,56 cases in each group.The two groups were treated with ziprasidone and aripiprazole for 3 months.Psychiatric symptoms and blood lipids before and after treatment were compared between the two groups.Results:In terms of positive score,negative score,general psychopathological score and total PANSS score,there was no statistically significant difference between the two groups before and after treatment(P>0.05).Compared with before treatment,the ziprasidone group positive scale,[(19.91±5.84)vs(19.91±5.84)points]negative scale,[(15.58±4.45)vs(19.21±6.53)points]general psychopathology,[(36.39±7.75)vs(48.11±9.35)points]PANSS[(67.79±15.87)vs(87.23±21.72)points]were lower than before treatment;Aripiprazole group positive scale,[(16.16±3.80)vs(19.90±5.86)points]negative scale,[(15.49±5.16)vs(19.20±6.55)points]general psychopathology,[(35.65±7.42)vs(48.10±9.34)points]PANSS[(67.30±16.38)vs(87.20±21.75)points]were lower than before treatment,and the difference was statistically significant(P<0.05).In terms of TC,TG,LDL-C and HDL-C,there was no statistically significant difference between the two groups before and after treatment(P>0.05).Conclusion:In the treatment of patients with first-episode schizophrenia,the use of ziprasidone and aripiprazole can significantly improve mental symptoms.There is no significant difference in the efficacy of the two drugs,and there is no significant effect on blood lipids.