ceRNA网络在肺癌中的研究进展

Recent research advances in the relationship between competing endogenous RNA and lung neoplasma

非编码RNA(non-coding RNAs,ncRNAs)可以通过"竞争",即依靠共同的miRNA反应元件竞争性结合而构建成一错综复杂的ceRNA网络。研究表明,在人类的多种癌症中存在多种ncRNAs表达异常,包括肺癌。在肺癌中,我们发现了多种ceRNA-miRNA-mRNA信号轴,且该轴已经被证明参与肺癌的发生、侵袭、转移、耐药以及预后等生物学过程,能够成为早期肺癌诊断的一种生物学标记物和治疗新靶点。本文即围绕ceRNA网络成员在肺癌细胞中的差异性表达及其特异性改变对肺癌的影响做一阐述。

Non-coding RNAs can be constructed into a complex network of ceRNA by competitive combination of common microRNA recognition sequences(MREs).At present,abnormal expression of non-coding RNAs has been found in many human cancers,including lung cancer.More over,many kinds of ceRNA-microRNA-RNA have been found,which have been proved to be involved in the biological processes of lung cancer,such as occurrence,invasion,metastasis,drug resistance and prognosis.This review focuses on the differential expression of ceRNA network members in lung cancer cells and the effects of their specific changes on lung cancer.