拉贝洛尔片联合硝苯地平片治疗妊娠高血压的效果及对患者生化指标和妊娠结局的影响

Efficacy of Labetalol Tablets Combined with Nifedipine Tablets in Treatment of Pregnancy-induced Hypertension and Its Effects on Patients’Biochemical Indexes and Pregnancy Outcomes

目的探讨拉贝洛尔片联合硝苯地平片治疗妊娠高血压的效果及对患者生化指标和妊娠结局的影响。方法选取2016年1月至2017年6月就诊于东莞市妇幼保健院的妊娠高血压患者82例作为研究对象,按照随机数字表法分为对照组和观察组,每组41例。对照组给予硫酸镁治疗,观察组在对照组基础上采用拉贝洛尔片联合硝苯地平片治疗。比较两组患者临床疗效、生化指标[血肌酐(Cr)、尿素氮(BUN)、D-二聚体(D-dimer)、纤维蛋白原(Fib)、凝血酶时间(TT)、活化部分凝血酶时间(APTT)]、妊娠结局(剖宫产、早产、宫缩乏力、产后大出血、胎儿窘迫、新生儿窒息、围生儿死亡发生情况)。结果观察组患者治疗有效率(95.12%)明显高于对照组(82.93%)(P<0.05);治疗后,观察组BUN、Cr、D-dimer、Fib明显低于对照组,TT、APTT明显高于对照组,差异有统计学意义(P<0.05);治疗后观察组剖宫产、早产、宫缩乏力、围生儿死亡与对照组比较,差异无统计学意义(P>0.05),产后大出血、胎儿窘迫、新生儿窒息发生率明显低于对照组(P<0.05)。结论拉贝洛尔片联合硝苯地平片与硫酸镁治疗妊娠高血压疗效显著,可以有效降低血压、改善肾功能和凝血功能,优化妊娠结局。

Objective To explore efficacy of labetalol tablets combined with nifedipine tablets in treatment of pregnancyinduced hypertension and its effects on patients’biochemical indicators and pregnancy outcomes.Methods A total of 82 patients of pregnancy-induced hypertension who were admitted to Dongguan City Maternal and Child Health Hospital from January 2016 to June 2017 were selected as research subjects.According to the random number table method,they were divided into control group and observation group,with 41 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with labetalol tablets combined with nifedipine tablets on the treatment basis of the control group.Clinical efficacy,biochemical indicators[serum creatinine(Cr),blood urea nitrogen(BUN),D-dimer,fibrinogen(Fib),thrombin time(TT),and activated partial thrombin time(APTT)]and pregnancy outcomes(cesarean section,premature delivery,uterine atony,postpartum hemorrhage,fetal distress,neonatal asphyxia,and perinatal death)in the 2 groups were compared.Results The total effective rate in the observation group(95.12%)was significantly higher than that in the control group(82.93%)(P<0.05).After the treatment,the BUN,Cr,D-dimer and Fib in the observation group were significantly lower than those in the control group,and the TT and APTT were significantly higher than those in the control group,with statistically significant differences(P<0.05).After the treatment,the cesarean section,premature delivery,uterine atony and perinatal death were not significantly different from those in the control group(P>0.05),while the incidences of postpartum hemorrhage,fetal distress and neonatal asphyxia were significantly lower than those in the control group(P<0.05).Conclusion Labeolol tablets combining with nifedipine tablets and magnesium sulfate in the treatment of pregnancy-induced hypertension is significantly effective,which can effectively decrease blood pressure,improve renal function and blood coagulation,and optimize pregnancy outcomes.