丁苯酞软胶囊联合高压氧治疗血管性痴呆患者的临床疗效和对血液指标的影响

Clinical Efficacy of Butylphthalide Soft Capsules Combined with High Pressure Oxygen in Treatment of Vascular Dementia Patients and Its Effects on Blood Parameters

目的探讨丁苯酞软胶囊联合高压氧治疗血管性痴呆患者的临床疗效和对血液指标的影响。方法选取2014年12月至2018年12月沈阳医学院附属中心医院神经内一科收治的90例血管痴呆患者作为研究对象,将所有患者按照入院顺序随机分为观察组和对照组,各45例。对照组给予高压氧治疗,观察组在对照组基础上采用丁苯酞软胶囊治疗。比较两组血清丙二醛(MDA)、超氧化物歧化酶(SOD)及血浆转化生长因子-β(TGF-β)、胰岛素样生长因子-1(IGF-1)、细胞间黏附分子-1(IGAM-1)、同型半胱氨酸(Hcy),采用临床痴呆评定量表(CDR)对患者治疗前后痴呆程度进行评价。结果治疗前,两组患者MDA和SOD比较,差异无统计学意义(P>0.05);治疗后,两组MDA降低,SOD升高,且观察组患者各项指标优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者血浆相关指标比较,差异无统计学意义(P>0.05);治疗后,两组TGF-β、IGF-1升高,IGAM-1、Hcy降低,且观察组各项指标优于对照组,差异有统计学意义(P<0.05)。治疗前,观察组与对照组的CDR评分分别为(2.11±0.34)分、(2.05±0.39)分,差异无统计学意义(P>0.05);治疗后,观察组CDR评分为(0.82±0.12)分,明显低于对照组的(1.08±0.16)分,差异有统计学意义(P<0.05)。结论丁苯酞胶囊联合高压氧治疗血管性痴呆患者的临床效果显著。

Objective To explore clinical efficacy of butylphthalide soft capsules combined with high pressure oxygen(HPO)in treatment of vascular dementia patients and its effects on blood indexes.Methods A total of 90 patients with vascular dementia admitted to DepartmentⅠof Neurology,Central Hospital Affiliated to Shenyang Medical College from December 2014 to December 2018 were selected as subjects of this study.All the patients were randomly assigned to observation group and control group in the order of admission,with 45 cases in each group.The control group was treated with HPO,while the observation group was given butylphthalide soft capsules on the treatment basis of the control group.Serum malonaldehyde(MDA),superoxide dismutase(SOD),plasma transforming growth factor-β(TGF-β),insulin-like growth factor-1(IGF-1),intercellular adhesion molecule(IGAM-1)and Homocysteine(Hcy)in the 2 groups were compared.Clinical dementia rating scale(CDR)was used to evaluate degrees of dementia before and after the treatment.Results Before the treatment,there was no significant difference in the MDA and SOD between the 2 groups(P>0.05).After the treatment,the MDA was decreased and the SOD was increased in the 2 groups,while the indexes in the observation group were significantly better than those in the control group,with statistically significant differences(P<0.05).Before the treatment,there was no statistically significant difference between the 2 groups in the plasma related indexes(P>0.05).After the treatment,the TGF-βand IGF-1 in the 2 groups were increased,while the IGAM-1 and Hcy were decreased.The indexes in the observation group were significantly better than those in the control group,and the differences were statistically significant(P<0.05).The CDR scores in the observation group and the control group before the treatment were(2.11±0.34)and(2.05±0.39),respectively,without statistically significant difference(P>0.05).After the treatment,the CDR score in the observation group was(0.82±0.12),which was significantly lower than that in the control group(1.08±0.16),with statistically significant difference(P<0.05).Conclusion Butylphthalide capsules combining HPO has significant clinical efficacy in the treatment of vascular dementia.