超早期静脉溶栓治疗急性脑梗死患者的有效性及安全性

Safety and Effectiveness of Ultra Early Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction

目的探讨超早期静脉溶栓治疗急性脑梗死患者的有效性及安全性。方法选取2016年1月至2019年8月就诊于盘锦辽油宝石花医院神经内科的134例急性脑梗死患者作为研究对象,根据治疗方法不同分为两组,每组67例,其中对照组给予纤溶酶注射液治疗,观察组给予阿替普酶溶栓治疗,比较两组临床疗效、神经功能缺损评分及不良反应发生情况。结果观察组治疗有效率高于对照组(P<0.05);治疗前两组神经功能缺损评分比较差异无统计学意义(P>0.05),观察组治疗6 h、治疗24 h评分低于对照组对应时间(P<0.05);观察组不良反应发生率为2.99%,低于对照组的13.43%(P<0.05)。结论超早期静脉阿替普酶溶栓治疗急性脑梗死疗效显著,可有效改善患者神经功能缺损,不良反应少。

Objective To explore the safety and effectiveness of ultra early intravenous thrombolysis in the treatment of acute cerebral infarction.Methods A total of 134 patients in the Department of Neurology,Liaoyoubaoshihua Hospital,with acute cerebral infarction from January 2016 to August 2019 were analyzed retrospectively.According to the different treatment methods,they were divided into 2 groups,with 67 cases in each group.The control group was treated with plasmin injection,and the study group was treated with ateplase thrombolysis.The clinical effects,neurological deficit score and adverse reaction rate of the 2 groups were compared.Results The effective rate of treatment in the study group was higher than that in the control group(P<0.05);there was no significant difference between the 2 groups before treatment(P>0.05).The scores of 6 hours and 24 hours in the study group were lower than that in the control group(P<0.05);the incidence of adverse reactions in the study group was 2.99%,lower than 13.43%in the control group(P<0.05).Conclusion The therapeutic effects of ultra early intravenous thrombolysis of acute cerebral infarction is significant,which can improve the neurological deficit score and has few adverse reactions.