健康体检人群血清25羟维生素D与超敏C反应蛋白的关联性研究

Association between serum 25-hydroxyvitamin D and high-sensitivity C reactive protein levels in health check-ups population

目的探讨健康体检人群血清25羟维生素D[25-(OH)D]水平和超敏C反应蛋白(hs-CRP)的关系。方法以合肥市某单位746名健康体检人员为研究对象,其中男性489人,占65.5%,年龄为(47.2±15.6)岁。通过问卷调查方法收集人口统计学和疾病信息等,并测定血清25-((OH))D和hs-CRP。将受检者按照25-(OH)D水平分为3组:非缺乏组(≥50 nmol/L)、缺乏组(25~<50 nmol/L)、严重缺乏组(<25 nmol/L)。将hs-CRP按75%百分位数分为正常组和高值组。25-(OH)D和hs-CRP的关联性采用多因素Logistic回归分析。结果在维生素D严重缺乏组、缺乏组和非缺乏组中hs-CRP高值发生率分别为29.8%、26.4%和17.0%,差异具有统计学意义(χ²=6.471,P<0.05);Logistic回归分析显示,25-(OH)D缺乏组和严重缺乏组hs-CRP高值的发生率均高于25-(OH)D非缺乏组,OR值(95%CI)分别为1.851(1.122~3.053)和2.369(1.227~4.573),差异具有统计学意义(P<0.05)。结论血清25羟维生素D缺乏是成人hs-CRP高值的危险因素,对维生素D缺乏人群的营养干预可能有利于降低机体炎症水平。

Objective To explore the association between serum 25-hydroxyvitamin D[25-(OH)D]and high-sensitivity C reactive protein(hs-CRP)levels in health check-ups population.Methods A total of 746 patients who underwent health check-ups at an enterprise unit in Hefei city were selected as the study subjects with an average age of(47.2±15.6)years and 489 males,accounting for 65.5%.Demographical and disease information was collected through questionnaires.Serum 25-(OH)D and hs-CRP levels were measured.The subjects were divided into three groups according to the 25-(OH)D level:non-deficient group(≥50 nmol/L),deficient group(25 nmol/L to 49.9 nmol/L),severely deficient group(<25 nmol/L).C-reactive protein was divided into normal group and high value group by 75%percentile.Multivariate logistic regression was used to analyze the relationship between 25-(OH)D and hs-CRP levels.Results The proportions of high CRP levels in the severely deficient,deficient,and non-deficient groups were 29.8%,26.4%,and 17.0%,respectively,and the difference was statistically significant(χ²=6.471,P<0.05).Logistic regression analysis showed that,compared with the non-deficient group of 25-(OH)D,the odds ratios values(95%CI)of the high values of hs-CRP in the deficient group and the severely deficient group of 25-(OH)D were 1.851(1.122 to 3.053)and 2.369(1.227 to 4.573),respectively.Conclusions Serum 25-(OH)D level is a risk factor for hs-CRP in adults.Nutritional intervention in vitamin D deficient population may be beneficial to reduce the level of inflammation.