恢复期血浆疗法在新型冠状病毒感染中的应用

Application of convalescent plasma therapy on novel coronavirus infection

由新型冠状病毒(2019-nCoV)感染导致的新型冠状病毒肺炎(COVID-19)已在全球范围暴发,虽积极救治,但仍有大量的重症患者,临床治疗压力巨大。恢复期血浆疗法利用感染后康复患者血浆中的特异性抗体治疗疾病,已在历史上多种重大传染病疫情中发挥作用,但也存在一定的局限性。目前尚无特效药物治疗的COVID-19,临床已在尝试使用恢复期血浆疗法并取得了一定疗效。本文通过讨论恢复期血浆疗法的历史、机制及在SARS等病毒性疾病中的应用经验,为恢复期血浆疗法在COVID-19的临床应用提供参考。

Coronavirus Disease 2019(COVID-19)caused by 2019-nCoV was in an outbreak globally.A large number of severe cases lead to strong clinical pressure even treated actively.Convalescent plasma(CP)therapy refers to a therapy infusing plasma from recovered donors into other infected individuals.It has played an important role in conquering variety of epidemics over a century with some limitations.Considering the absence of specific treatments,CP has been used for treating COVID-19 and achieved some efficacies.This article provides a reference for clinical application of CP therapy in COVID-19,by discussing the history,mechanism and application of CP therapy in viral diseases such as SARS.