维生素K与2型糖尿病关系的研究进展

Research progress of relationship between vitamin K and type 2 diabetes

目的:系统回顾有关维生素K与2型糖尿病及其生物标记物的研究,评估维生素K在预防2型糖尿病发生和发展中的作用。方法:以vitamin K和type 2 diabetes、维生素K和2型糖尿病的相关检索词进行组合,系统检索PubMed、EMBASE、中国知网、万方数据知识服务平台从建库至2018年11月间收录的文献报道。结果:共纳入1篇中文文献和12篇英文文献。在6项观察性研究中,有5项结果表明较高的膳食维生素K摄入及血浆维生素K水平与2型糖尿病发病风险的降低有关。而在6篇临床干预研究中,5篇均发现维生素K1或K2的补充可对机体胰岛素代谢产生积极影响。另有1篇孟德尔随机化研究,提示较高的维生素K1浓度可能降低2型糖尿病的发病风险。结论:维生素K在2型糖尿病的预防和控制中有着重要作用,而这一作用可能与维生素K改善机体胰岛素代谢从而影响血糖水平有关。

Objective To systematically review research on the association between vitamin K and type 2 diabetes and diabetes-related biomarkers in humans,and evaluate the role of vitamin K in the prevention of type 2 diabetes.Methods"Vitamin K","type 2 diabetes"and related terms were searched in PubMed,EMBASE,China National Knowledge Infrastructure(CNKI)and Wanfang Med Online up to November 2018.Results A total of 1 Chinese and 12 English articles were included.Among 6 observational studies,5 of them showed that higher dietary vitamin K intake and plasma vitamin K level were associated with the decrease of the risk of type 2 diabetes.Among 6 clinical intervention studies,5 of them indicated that the supplementation of vitamin K1 or K2 could have positive influence on insulin metabolism.One Mendelian randomization study showed higher circulation vitamin K level might reduce the risk of type 2 diabetes.Conclusion Vitamin K plays an important role in the prevention and control of type 2 diabetes,which may be related to the improvement of insulin metabolism and blood glucose level.