罕见并发于胃癌的抗Yo抗体阳性副肿瘤性小脑变性一例并文献复习

Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma:one case report and literature review

报道1例急性起病、以共济失调和构音障碍为主要表现的男性患者,该患者癌胚抗原、非小细胞肺癌抗原、肿瘤相关抗原72-4显著升高,血抗Yo抗体阳性,胃镜及活组织检查提示胃癌,行胃癌根治手术治疗后随访症状较术前好转,可以明确诊断为并发于胃癌的抗Yo抗体阳性的副肿瘤性小脑变性。在临床工作中如果遇到共济失调或构音障碍的患者,需要考虑副肿瘤性小脑变性的可能,应积极寻找肿瘤的证据,以便尽早确诊并进一步治疗,以免造成漏诊或误诊。

A male patient of acute onset is reported,whose main clinical manifestations were ataxia and dysarthria,with elevated carcinoembryonic antigen,non-small cell lung cancer antigen,carbohydrate antigen 72-4,positive anti-Yo antibody.The patient′s gastroscopy and biopsy result suggested gastric cancer,and his symptoms got better after radical surgery.Anti-Yo-associated paraneoplastic cerebellar degeneration complicated with gastric adenocarcinoma was diagnosed.If encountering cases of ataxia or dysarthria in clinical work,the possibility of paraneoplastic cerebellar degeneration should be considered and evidence for tumor should be searched,so as to avoid missed diagnosis or misdiagnosis.