基于KEGG通路和蛋白互作对慢性心力衰竭靶点基因的筛选

Screen of target genes for chronic heart failure based on KEGG pathway and protein-protein interaction network

目的:运用KEGG通路和蛋白互作筛选出慢性心力衰竭(CHF)靶点基因。方法:以“chronic heart failure”为关键词在NCBI数据库中检索CHF相关靶点基因,并运用R语言相关数据包进行KEGG通路分析,获得CHF的关键通路。对关键通路分析,筛选出CHF相关靶点基因和关键靶点基因。结果:在NCBI数据库检索到CHF相关靶点基因119个,获得关键通路后分析获得9个CHF靶点基因,为IL10,IL6,NOS3,TNF,VCAM1,AGT,EDN1,IFNG,IL17A,5个CHF关键靶点基因,分别为IL6,NOS3,TNF,VCAM1,IL10。结论:运用KEGG通路和蛋白互作筛选出CHF关键靶点基因,为进一步研究CHF的分子机制以及新药的开发奠定了基础。

Objective:To search the target genes of"chronic heart failure"(CHF)by using KEGG pathway and protein-protein interaction.Method:Using"chronic heart failure"as the key word,the target genes related to CHF were searched in the NCBI database,and the R language related data packages were used to analyze the KEGG pathway to obtain a KEGG pathway of CHF.CHF-related target genes and key target genes were screened for the analysis of key pathways.Result:The 119CHF-related target genes were retrieved from the NCBI database.After analyzing the key pathways,9CHF target genes were obtained,including IL10,IL6,NOS3,TNF,VCAM1,AGT,EDN1,IFNG,IL17A.And 5CHF key target genes were IL6,NOS3,TNF,VCAM1,and IL10.Conclusion:The key target genes of CHF were screened out using KEGG pathway and protein-protein interaction,which will lay the foundation for further research on the molecular mechanism of CHF and the development of new drugs.