桂枝芍药知母汤加减方治疗类风湿性关节炎寒热错杂证的临床效果及安全性

Clinical effect and safety of modified Guizhi Shaoyao Zhimu decoction in the treatment of rheumatoid arthritis with cold-heat complicated syndrome

目的探讨桂枝芍药知母汤加减方治疗类风湿性关节炎寒热错杂证的临床效果及安全性。方法2017年6月至2019年5月选择我院收治的60例类风湿性关节炎寒热错杂证患者作为研究对象,依据随机数字表法将其分为对照组和观察组,每组30例,对照组给予甲氨蝶呤治疗,观察组在甲氨蝶呤基础上给予桂枝芍药知母汤加减方治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的关节压痛、关节肿胀、晨僵、疾病活动度评分均降低,且观察组低于对照组(P<0.05)。治疗后,两组的生活质量评分均升高,且观察组高于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论桂枝芍药知母汤加减方可提高类风湿性关节炎寒热错杂证患者的临床疗效,有利于提高患者的生活质量,且安全性良好。

Objective To explore the clinical effect and safety of modified Guizhi Shaoyao Zhimu decoction in the treatment of rheumatoid arthritis with cold-heat complicated syndrome.Methods From June 2017 to May 2019,60 rheumatoid arthritis patients with cold-heat complicated syndrome treated in our hospital were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 30 cases in each group.The control group was treated with methotrexate,and the observation group was treated with modified Guizhi Shaoyao Zhimu decoction on the basis of methotrexate.The treatment effect of the two groups was compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the scores of joint tenderness,joint swelling,morning stiffness and disease activity degree in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the quality of life scores of the two groups increased,and that in the observation group was higher than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Guizhi Shaoyao Zhimu decoction can improve the clinical effect of rheumatoid arthritis patients with cold-heat complicated syndrome,which is conducive to improving the quality of life of patients and has good safety.