溃疡性结肠炎患者内镜严重程度与实验室检查指标相关性分析

Analysis on correlation between severity of ulcerative colitis patients under endoscopy and laboratory examination indexes

目的探讨溃疡性结肠炎(UC)患者内镜下严重程度与血常规、凝血功能、血脂、血尿酸等实验室指标的相关性。方法回顾性收集2018年1月至12月于西安交通大学第二附属医院收治的90例确诊UC患者的临床资料,根据患者Mayo肠镜评分分为轻、中、重3组,比较3组患者实验室指标差异,分析Mayo肠镜评分和实验室指标的相关性。结果轻、中、重3组UC患者血小板[(205.00±61.18)×109/L比(240.33±82.90)×109/L比(285.55±107.60)×109/L,P=0.020]、血红蛋白[(129.70±16.22)g/L比(135.35±20.40)g/L比(121.33±27.82)g/L,P=0.034]、低密度脂蛋白[(2.44±0.50)mmol/L比(2.54±0.67)mmol/L比(2.10±0.62)mmol/L,P=0.010]、胆固醇[(4.07±0.60)mmol/L比(4.02±0.94)mmol/L比(3.50±0.80)mmol/L,P=0.017]和纤维蛋白原[(2656.00±371.54)mg/L比(3034.50±826.52)mg/L比(3390.26±1013.61)mg/L,P=0.039]组间差异有统计学意义,且检测值水平与Mayo肠镜评分均具有相关性(P<0.05),其中低密度脂蛋白、胆固醇与Mayo肠镜评分呈负相关(P<0.05);血小板、纤维蛋白原与UC肠镜评分呈正相关(P<0.05)。结论通过对UC患者相关实验室指标的检测,可协助评估UC患者的肠道情况。

Objective To examine the correlation of the severity of ulcerative colitis(UC)under endoscopy with blood routine,coagulation,lipid,uric acid and other laboratory indexes.Methods Clinical data of 90 UC patients in The Second Affiliated Hospital of Xi′an Jiaotong University from January to December 2018 were retrospectively collected.The patients were divided into three groups as light,medium and heavy according to Mayo colonoscopy score.The laboratory indexes were compared among 3 groups and the correlations between Mayo colonoscopy score and laboratory indexes were analyzed.Results Among light,medium,and heavy groups,differences of the platelet count[(205.00±61.18)×109/L vs.(240.33±82.90)×109/L vs.(285.55±107.60)×109/L,P=0.020],hemoglobin[(129.70±16.22)g/L vs.(135.35±20.40)g/L vs.(121.33±27.82)g/L,P=0.034],low-density lipoprotein(LDL)[(2.44±0.50)mmol/L vs.(2.54±0.67)mmol/L vs.(2.10±0.62)mmol/L,P=0.010],cholesterol[(4.07±0.60)mmol/L vs.(4.02±0.94)mmol/L vs.(3.50±0.80)mmol/L,P=0.017],fibrinogen[(2656.00±371.54)mg/L vs.(3034.50±826.52)mg/L vs.(3390.26±1013.61)mg/L,P=0.039]were statistically significant(all P<0.05).Mayo colonoscopy score was negatively correlated with LDL and cholesterol(all P<0.05),while it was positively correlated with platelet count and fibrinogen(all P<0.05).Conclusion Testing the relevant laboratory indexes of UC patients can help evaluate the intestinal condition.