参松养心胶囊治疗快速性心律失常的疗效及其对患者血流流变学和心功能的影响

Effect of Shensong Yangxin capsule on hemorheology and cardiac function in patients with tachyarrhythmia

目的探讨参松养心胶囊治疗快速性心律失常的疗效及其对患者血流流变学及心功能的影响。方法选择2013年6月至2018年6月在台州骨伤医院进行治疗的快速性心律失常患者86例为研究对象。依据随机数字表法将患者分为对照组和观察组,每组43例。对照组患者使用盐酸胺碘酮片进行治疗,观察组患者在对照组的基础上使用参松养心胶囊进行治疗。治疗8周后,比较分析两组患者的临床疗效、血流流变学指标以及心功能。结果观察组总有效率为93.02%(40/43),显著高于对照组的76.74%(33/43),差异有统计学意义(χ^2=11.064,P<0.05)。治疗后,观察组血浆黏度、纤维蛋白原以及血细胞比容[(1.10±0.20)mPa/s、(1.69±0.36)g/L、(36.94±0.96)%]均低于对照组[(1.51±0.38)mPa/s、(3.02±0.75)g/L、(45.15±1.06)%],两组差异均有统计学意义(t=7.615、9.463、11.656,均P<0.05)。治疗后,观察组的左心室收缩期内径(LVDs)及左心室舒张期内径(LVDd)水平[(39.02±4.68)mm、(53.16±6.42)mm]均明显高于对照组[(35.48±4.05)mm、(47.99±5.09)mm],两组差异均有统计学意义(t=4.916、5.064,均P<0.05)。结论参松养心胶囊对快速性心律失常患者治疗疗效显著,能明显改善患者血流流变学指标和心功能,安全性较高,值得大力推广。

Objective To study the efficacy of Shensong Yangxin capsule in the treatment of tachyarrhythmia and its effect on the hemorheology and cardiac function of patients.Methods From June 2013 to June 2018,86 patients with tachyarrhythmia who were treated in Taizhou Orthopedic Hospital were enrolled.The patients were divided into control group and observation group according to the random number table method,with 43 cases in each group.The patients in the control group were treated with amiodarone hydrochloride tablets,the patients in the observation group were treated with Shensong Yangxin capsule on the basis of the control group.After 8 weeks,the clinical efficacy,hemorheology and cardiac function of the two groups were compared and analyzed.Results The total effective rate of the observation group was 93.02%(40/43),which was significantly higher than 76.74%(33/43)of the control group(χ^2=11.064,P<0.05).The plasma viscosity,fibrinogen and hematocrit in the observation group[(1.10±0.20)mPa·s,(1.69±0.36)g/L,(36.94±0.96)%]were lower than those in the control group[(1.51±0.38)mPa·s,(3.02±0.75)g/L,(45.15±1.06)%],the differences were statistically significant between the two groups(t=7.615,9.463,11.656,all P<0.05).After treatment,the LVDs and LVDd in the observation group[(39.02±4.68)mm,(53.16±6.42)mm]were significantly higher than those in the control group[(35.48±4.05)mm,(47.99±5.09)mm],the differences were statistically significant between the two groups(t=4.916,5.064,all P<0.05).Conclusion Shensong Yangxin capsule has significant therapeutic effect on patients with tachyarrhythmia,which can significantly improve the hemorheology and heart function of patients,and it is safe and worthy of promotion.