注射用丹参多酚酸盐的临床应用评价

Evaluation of clinical application of salvianolate for injection

目的评估浙江省立同德医院注射用丹参多酚酸盐临床应用的合理性。方法采用随机抽样法抽取浙江省立同德医院2018年3-11月使用注射用丹参多酚酸盐的病例560例,对注射用丹参多酚酸盐的适应证、用法用量、给药途径、溶媒选择、溶媒浓度、用药疗程、药品配伍、用药禁忌和不良反应等进行回顾性分析。结果560例中,适应证合理率为26.96%(151/560),用法用量的合理率为99.82%(559/560),给药途径合理率为100.00%(560/560),溶媒选择合理率为95.00%(532/560),溶媒浓度合理率为67.86%(380/560),用药疗程合理率为61.07%(342/560),药品配伍合理率为100.00%(560/560),凝血功能的用药禁忌合理率为94.46%(529/560),肝功能的用药禁忌合理率为90.18%(505/560),不良反应发生率为1.61%(9/560),主要表现为头痛头晕、皮疹瘙痒、恶心、静脉炎、胸闷。结论注射用丹参多酚酸盐的临床应用不合理现象主要体现在适应证、用药疗程和溶媒浓度选择不合理等方面,亟待进一步规范其合理用药。

Objective To investigate the clinical application of salvianolate for injection in Tongde Hospital of Zhejiang Province and evaluate its rationality of injection.Methods From March 2018 to November 2018,560 patients treated with salvianolate for injection in Tongde Hospital of Zhejiang Province were selected by random sampling method.The indications,usage and dosage,route of administration,choice of vehicle,concentration of vehicle,course of treatment,compatibility,contraindications and adverse reactions of salvianolate for injection were analyzed retrospectively.Results Totally 560 inpatients received salvianolate for injection were collected,about 26.96%(151/560)was consistent with the indication,99.82%(559/560)with a correct administration dosage and frequency,100.00%(560/560)with right administration route,95.00%(532/560)with a right solvent selection,67.86%(380/560)with correct solvent concentration,61.07%(342/560)with a correct treatment course,100.00%(560/560)with a right medicine combination,about 94.46%(529/560)was consistent with coagulation function contraindication,about 90.18%(505/560)was consistent with liver function contraindication.The incidence of adverse reactions was 1.61%(9/560).Conclusion In the clinical application of salvianolate for injection,a high rate of unreasonable usage is found in indication,treatment course and solvent selection.Because of the serious problems in the use of salvianolate injection,it should be used strictly to ensure clinical medication safety.