不同剂量艾司奥美拉唑镁的四联方案治疗幽门螺杆菌感染性胃炎的效果比较

Comparison of efficacy of quadruple regimen with different doses of esomeprazole magnesium in the treatment of helicobacter pylori infection gastritis

目的比较不同剂量艾司奥美拉唑镁的四联方案治疗幽门螺杆菌(Hp)感染性胃炎的效果。方法回顾性分析运城市中心医院2016年9月至2018年10月诊治的Hp感染性胃炎患者100例的临床资料,均采取以艾司奥美拉唑镁为基础的四联方案,并按艾司奥美拉唑镁用药剂量不同分组:对照组(n=50)应用标准剂量20 mg,研究组(n=50)应用高剂量40 mg,比较两组患者Hp根除率、不良反应发生率、总体疗效以及复发率差异。结果研究组Hp根除率(98.0%)高于对照组(84.0%)(χ^2=4.396,P=0.036),胃炎总体有效率(96.0%)高于对照组(82.0%)(χ^2=5.005,P=0.025),复发率(0.0%)低于对照组(12.0%)(χ^2=4.433,P=0.035);研究组不良反应发生率(12.0%)与对照组(6.0%)差异无统计学意义(χ^2=0.488,P=0.485)。结论高剂量的艾司奥美拉唑镁的四联方案根除Hp感染性胃炎效果更佳,Hp根除率高,安全有效,可值得临床推广。

Objective To compare the efficacy of quadruple regimens with different doses of esomeprazole magnesium in the eradication of helicobacter pylori(Hp)infection gastritis.Methods From September 2016 to October 2018,the clinical data of 100 patients with Hp infection gastritis in Yuncheng Central Hospital were retrospectively analyzed.All patients received esomeprazole magnesium based quadruple scheme,and according to the different dosage of esomeprazole magnesium,the patients were divided into two groups:control group(n=50)received standard dose of 20 mg,study group(n=50)received a high dose of 40 mg.The Hp eradication rate,incidence of adverse reactions,the overall curative effect and the recurrence rate were compared between the two groups.Results The eradication rate of Hp in the study group(98.0%)was higher than that in the control group(84.0%)(χ^2=4.396,P=0.036).The overall effective rate of gastritis in the study group(96.0%)was higher than that in the control group(2.0%)(χ^2=5.005,P=0.025),and the recurrence rate in the study group(0.0%)was lower than that in the control group(12.0%)(χ^2=4.433,P=0.035).The incidence of adverse reactions in the study group(12.0%)was not significantly different from that in the control group(6.0%)(χ^2=0.488,P=0.485).Conclusion The quadruple regimen with high dose of esomeprazole magnesium has better effect on the eradication of Hp infection gastritis with strong eradication,and it is safe and reliable,so it is recommended to promote.