白术厚朴汤加减对痰湿型代谢病患者血压、血糖、血脂的疗效观察

Observation on the curative effect of atractylodes macrocephala and magnolia officinalis decoction on blood pressure,blood glucose and blood lipid in treatment of metabolic syndrome of damp-phlegm pattern

目的研究代谢病痰湿型患者使用白术厚朴汤治疗后对血压、血糖、血脂的影响。方法选择2017年9月-2019年7月本院门诊及住院部收治的代谢病患者78例作为研究对象,按照治疗方式的不同随机分为对照组和观察组两组,每组各39例。对照组采用常规治疗方法,根据患者具体情况选择合适药物进行降糖、降压、调脂。观察组在常规治疗的基础上,使用白术厚朴汤加减。两个疗程后(8周)进行基础指标(腰围、BMI、血压SBP/DBP)、生化指标(血糖FPG、血脂TG、HDL-C)、中医证候积分、疗效评价、西药用量等指标评价。结果疗程结束后观察组各基础指标及生化指标均优于对照组(P<0.05);观察组中医证候积分(17.03±2.82)分,明显低于对照组的(21.08±3.17)分(P<0.05);观察组显效率(71.80%)及总有效率(97.44%)明显高于对照组(P<0.05);观察组使用西药药物品种及服药次数均少于对照组(P<0.05)。结论痰湿型代谢病患者在临床常规治疗时加用白术厚朴汤加减,可更有效地调节血压、血糖、血脂,降低体重,提高疗效,减少西药用量。

Objective To investigate the effects of atractylodes macrocephala and magnolia officinalis decoction on blood pressure,blood glucose and blood lipid in patients with metabolic syndrome(MS)of damp-phlegm pattern.Methods From September 2017 to July 2019,78 MS patients who met the inclusion criteria were selected from the outpatient and inpatient department of our hospital.They were divided into control group and observation group according to the therapy methods.In the control group,the 39 patients were treated with conventional treatment,and appropriate drugs were selected to treat hyperglycemia,hypertension and dyslipidemia according to the specific situation of the patients.In the observation group,the 39 patients were treated with conventional therapy and atractylodes macrocephala and magnolia officinalis decoction.After two courses of treatment(8 weeks),indicators were evaluated,including basic indicators:waist circumference,BMI,blood pressure(SBP/DBP);biochemical indicators:blood glucose(FPG),blood lipid(TG,HDL-C);TCM syndrome score;efficacy evaluation;dosage of western medicine.Results After the treatment course,all the basic indexes and biochemical indexes in the observation group were better than those in the control group(P<0.05).The TCM syndrome score in the observation group(17.03±2.82 points)was significantly lower than that(21.08±3.17 points)in the control group(P<0.05).The apparent efficiency(71.80%)and total effective rate(97.44%)of the observation group were significantly higher than that of the control group(P<0.05).The variety and frequency of western medicine used in the observation group were less than that in the control group(P<0.05).Conclusions During the routine clinical treatment of patients with metabolic syndrome of damp-phlegm pattern,the addition of atractylodes macrocephala and magnolia officinalis decoction could effectively regulate blood pressure,blood sugar and blood lipids,reduce body weight,improve the curative effect,and reduce the dosage of western medicine.