3.0T MR动态增强曲线联合ADC用于乳腺良恶性病变鉴别诊断的敏感性及特异性分析

Sensitivity and specificity analysis of 3.0T MR dynamic contrast curve combined with ADC for differential diagnosis of benign and malignant breast lesions

目的:分析3.0T MR动态增强曲线联合ADC用于乳腺良恶性病变鉴别诊断中的应用价值。方法:将我院2017年1月-2019年3月间收治乳腺病变患者依照病理诊断的良恶性分为良性病变组及恶性病变组;对受试者采用3.0T MR进行检查,绘制ROC曲线分析动态增强曲线联合ADC用于乳腺良恶性病变鉴别。结果:良性病变组与恶性病变组患者动态增强曲线存在明显差异,且差异有统计学意义(P<0.05),恶性病变组患者ADC值明显低于良性病变组,且差异有统计学意义(P<0.05);动态增强曲线分析结果为乳腺良性病变的73例,ADC值分析结果为乳腺良性病变的72例,联合应用分析结果为乳腺良性病变的70例;动态增强曲线与ADC值联合应用鉴别诊断乳腺良恶性的敏感度、特异度及AUC均明显高于各指标单独应用,且差异有统计学意义(P<0.05)。结论:采用3.0T MR动态增强曲线联合ADC对乳腺良恶性病变进行鉴别诊断的敏感度及特异度均明显高于增强曲线或ADC单独应用。

Objective:To analyze the application value of 3.0 T MR dynamic enhancement curve combined with ADC in differential diagnosis of benign and malignant breast lesions.Methods:The patients with breast lesions from January 2017 to March 2019 in our hospital were divided into benign lesion group and malignant lesion group according to the pathological diagnosis.The subjects were examined with 3.0 T MR and the ROC curve analysis was dynamically enhanced.Curve combined with ADC was for the differential diagnosis of benign and malignant breast lesions.Results:There were significant differences in the dynamic enhancement curves between the benign lesion group and the malignant lesion group,and the difference was statistically significant(P<0.05).The ADC value of the benign lesion group was significantly lower than that of the malignant lesion group,and the difference was statistically significant(P<0.05).The results of dynamic enhancement curve analysis were73 cases of benign breast lesions.The results of ADC analysis were 72 cases of benign breast lesions.The combined application analysis showed 70 cases of benign breast lesions.The combination of dynamic enhancement curve and ADC value was used to differentially diagnose breast.The sensitivity,specificity and AUC of benign and malignant were significantly higher than those of each index,and the difference was statistically significant(P<0.05).Conclusion:The sensitivity and specificity of the differential diagnosis of benign and malignant breast lesions using 3.0 T MR dynamic enhancement curve combined with ADC were significantly higher than those of the enhancement curve or ADC alone.