美沙酮维持治疗者滥用苯二氮类药物情况调查

Investigation on Abuse of Benzodiazepines in Methadone Maintenance Therapy Patients and Nursing Countermeasures

目的:调查美沙酮维持治疗者滥用苯二氮类(BZD)药物情况并探讨相关影响因素,制订相应的干预对策。方法:选取广州市荔湾区和海珠区药物维持治疗点于2018年12月10-17日期间在治的本地服药人员288例为研究对象,对研究对象尿液中的苯二氮类和吗啡进行现场定性检测,将尿液中苯二氮类阳性者作为因变量与患者的社会人口学特征、海洛因滥用史、治疗情况以及尿吗啡检测结果运用非条件logistic进行分析。结果:在288例研究人员中,确认苯二氮类滥用者47例(16.3%),吗啡滥用者39例(13.5%)。通过非条件logistic回归分析表明,服用美沙酮剂量增高(OR=1.019,95%CI 1.006,1.032)会增加合并滥用苯二氮[艹卓]类的风险,吸毒方式为烫吸(OR=0.328,95%CI 0.162,0.663)会降低滥用的风险,性别、年龄、文化程度、居住状况、吸毒时间、美沙酮维持治疗时间等对发生滥用BZD行为无影响。结论:在2个门诊的美沙酮维持治疗患者中存在滥用苯二氮?类的行为,应对注射吸毒、美沙酮剂量偏高者予以关注,并采取有针对性的干预措施,以提高治疗效果。

Objective:This research aims to investigate the abuse of benzodiazepine (BZD) in methadone maintenance therapy patients,explore the related factors,and formulate corresponding nursing strategies.Methods:The research chooses 288 objects who are local patients in medical maintenance therapy points in Liwan District and Haizhu District of Guangzhou from December 10 to 17,2018.The morphine and benzodiazepines in the objects’ urine are detected.If the detection result is positive,the abuse of benzodiazepine as the dependent variable,along with the socio-demographic characteristics,heroin abuse history,treatment status and urine morphine test results of the patients,will be analyzed by the use of unconditional logistic.Results:The study shows that among the 288 objects,there are 47 benzodiazepine abusers (16.3%) and 39 morphine abusers (13.5%).Logistic regression analysis shows that taking larger dose of methadone dose (OR=1.019,95%CI 1.006,1.032) increases the risk of merger abuse of benzodiazepines (OR=0.328,95%CI 0.162,0.663) and reduces the risk of abuse,and that sex,living conditions,drug use time,and methadone maintenance treatment time etc.have no influence on BZD abuse behavior.Conclusion:Benzodiazepine abuse is found in the methadone maintenance treatment patients in two outpatient clinics;hence attention should be paid to those who abuse heroin and take high methadone dose,and intervention measures should be taken to improve the therapeutic effect.