TIA/轻型缺血性卒中患者认知功能障碍与血清尿酸及Aβ1-42浓度的相关性研究

The correlation of serum Aβ1-42,uric acid concentration and transient ischemic attack and minor stroke patients’cognitive impairment

目的探讨血尿酸、β淀粉样蛋白1-42(Aβ1-42)浓度与TIA/轻型缺血性卒中患者认知功能障碍的关系,为高危人群早期预报、早期干预提供理论依据。方法收集2019-01―12平煤神马医疗集团总医院神经内科收治的TIA/轻型缺血性卒中患者138例及健康志愿者70例。收集2组临床资料,以MoCA评分评估患者认知功能,比较各组血清尿酸、Aβ1-42浓度的差异,分析血清尿酸及Aβ1-42浓度与TIA/轻型缺血性卒中认知障碍的关系。结果TIA/轻型缺血性卒中认知障碍组血清尿酸浓度较认知功能正常组高(P=0.002),血Aβ1-42浓度低于认知功能正常组,差异有统计学意义(P=0.002)。多因素Logistic回归分析示血尿酸浓度OR=0.983,OR 95%CI=0.973~0.993,P=0.001,血Aβ1-42浓度OR=1.011,OR 95%CI=0.983~1.093,P=0.045。结论(1)TIA/轻型缺血性卒中认知功能障碍组患者血尿酸浓度较认知功能正常组高,血Aβ1-42浓度较认知功能正常组显著降低。(2)高浓度的血尿酸水平以及低浓度的血Aβ1-42水平是TIA/轻型缺血性卒中后认知障碍的独立危险因素。

Objective The study is to explore the correlation of serum Aβ1-42,uric acid concentration and transient ischemic attack and minor stroke patients’cognitive impairment.The purpose of the study is to provide a theoretical basis for early prediction and early intervention of high-risk populations in the early stages of the disease.Methods 138 patients with TIA/minor ischemic stroke and 70 cases of healthy volunteers were collected during January 2019 to December 2019 in neurology of our hospital.The clinical data of each group were collected,and the cognitive function of the patients was evaluated by MoCA score.Compared the differences of serum Aβ1-42,uric acid concentration of each group,and analyzed the relationship between concentration of serum Aβ1-42 and uric acid and cognitive impairment dysfunction after TIA/minor ischemic stroke.Results The serum uric acid concentration in the TIA/minor ischemic stroke cognitive impairment group was higher than that in the normal cognitive function group(P=0.002),and the concentration of serum Aβ1-42 was lower than the normal cognitive function group(P=0.002).The difference was statistically significant.Multi-factor Logistic regression analysis showed that serum uric acid concentration OR=0.983,OR 95%CI=0.973-0.993,P=0.001,and serum Aβ1-42 concentration OR=1.011,OR 95%CI=0.983-1.093,P=0.045.Conclusion①The serum uric acid concentration in the TIA/minor ischemic stroke cognitive impairment group was higher than that in the normal cognitive function group,and the concentration of serum Aβ1-42 was significantly lower than the normal cognitive function group.②High serum uric acid concentration and low serum Aβ1-42 concentration are independent risk factors for cognitive impairment after TIA/minor ischemic stroke.