放疗联合免疫检查点抑制剂治疗非小细胞肺癌研究进展

Research progress on radiotherapy combined with immune checkpoint inhibitor in the treatment of non-small cell lung cancer

免疫检查点抑制剂(ICI)的出现为非小细胞肺癌的治疗提供了新方法。而单用ICI的局限性促使临床医生开始探索放疗联合ICI的可行性。近期有关联合治疗的各项研究已初步揭示了其改变非小细胞肺癌治疗体系的巨大前景。本文从联合治疗的机制出发,综述有关联合治疗的基础研究和不同放疗方式联合ICI的临床进展。

The emergence of immune checkpoint inhibitors(ICI)provides a novel method for the treatment of non-small cell lung cancer(NSCLC).However,the limitation of ICI alone prompts clinicians to explore the feasibility of radiotherapy combined with ICI.Recent studies on this combined therapy have preliminarily revealed its significant prospects for changing the treatment system of NSCLC.From the perspective of the mechanism of combined therapy,this study reviewed the basic research on this combined therapy and the clinical progress on different radiotherapy combined with ICI.