八味沉香散的化学和药理研究进展

Chemical and pharmacological progress on a Tibetan folk medicine formula Bawei Chenxiang Powder

八味沉香散为藏族经典验方,由沉香、肉豆蔻、广枣、石灰华、乳香、木香、诃子(煨)和木棉花8味药组成,具有清心热、养心、安神等功效,临床多用于治疗冠心病、心绞痛等疾病。复方的组成药物中主要含有以倍半萜和三萜为主的萜类、以黄酮、木脂素、鞣质为主的多酚类成分。药理研究显示,八味沉香散在治疗心肌缺血、脑缺血、提高空间学习记忆力等方面均有一定疗效。该文从传统应用、化学成分、药理作用等方面对八味沉香散及其相关制剂归纳总结,为药效物质研究提供参考。

Bawei Chenxiang Powder is a traditional Tibetan folk medicine formula,consisting of resinous wood of Aquilaria sinensis,kernel of Myristica fragrans,fruit of Choerospondias axillaris,travertine,resin of Boswellia carterii or B.bhaw-dajiana,stem of Aucklandia lappa,fruit of Terminalia chebula(roasted),and flower of Gossampinus malabarica.It has the function of clearing heart heat,nourishing heart,tranquilizing mind,and inducing resuscitation,which has been used for the treatment of coronary heart disease and angina pectoris.Modern research shows that the medicine materials of this formula mainly contain terpenoids like sesquiterpenes and triterpenes and polyphenols like flavonoids,lignans,and tannins,displaying some pharmacological activities such as anti-myocardial ischemia,anti-cerebral ischemia,and spatial learning and memory promotion.This review summaries the traditional uses,chemical constituents,and pharmacological activities research progress,hopefully to provide a reference for clarification of its pharmacological active ingredients.