散风活络丸联合依达拉奉治疗急性脑梗死的临床研究

Clinical study on Sanfeng Huoluo Pills combined with edaravone in treatment of acute cerebral infarction

目的研究散风活络丸联合依达拉奉注射液治疗急性脑梗死的临床疗效。方法选取2017年10月—2019年10月新乡医学院第一附属医院收治的120例急性脑梗死患者为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组患者静脉滴注依达拉奉注射液,30 mg溶于生理盐水100 mL,在30 min内完成,1次/d;治疗组患者在对照组基础上口服散风活络丸,15丸/次,1次/d。两组患者持续治疗14d。观察两组患者治疗后临床疗效,对比两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel评分和炎症因子水平。结果治疗后,治疗组总有效率(96.67%)显著高于对照组(78.33%)(P<0.05)。治疗后,两组患者NIHSS评分显著降低,Barthel评分明显升高(P<0.05),且治疗组Barthel评分和NIHSS评分改善程度较大(P<0.05)。治疗后,两组患者C反应蛋白(CRP)、白细胞介素-8(IL-8)和白细胞介素-10(IL-10)水平均显著降低(P<0.05);并且治疗组血清炎性因子水平降低较多(P<0.05)。结论散风活络丸联合依达拉奉注射液治疗急性脑梗死具有较好的疗效,可改善临床症状,降低血清炎性因子水平,安全性较高,值得在临床上推广应用。

Objective To study the effect of Sanfeng Huoluo Pills combined with Edaravone Injection in treatment of acute cerebral infarction.Methods Patients(120 cases)with acute cerebral infarction in the First Affiliated Hospital of Xinxiang Medical University from October 2017 to October 2019 were randomly divided into control and treatment groups,and each group had 60 cases.Patients in the control group were iv administered with Edaravone Injection,30 mg added into normal saline 100 mL,infusion completed within 30 min,once daily.Patients in the treatment group were po administered with Sanfeng Huoluo Pills on the basis of the control group,15 pills/time,once daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacies were evaluated,and National Institute of Health stroke scale(NIHSS)score,Barthel score,and inflammatory factor in two groups were compared.Results After treatment,the total effective rate in the treatment group(96.67%)was significantly higher than that in the control group(78.33%)(P<0.05).After treatment,NIHSS scores in two groups were significantly decreased,but Barthel scores in two groups were significantly increased(P<0.05),and Barthel scores and NIHSS scores in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-8(IL-8),and interleukin-10(IL-10)in the two groups were significantly decreased(P<0.05),and the serum level of inflammatory factors in the treatment group were significantly lower than those in the control group decreased(P<0.05).Conclusion Sanfeng Huoluo Pills combined with Edaravone Injection has clinical curative effect in treatment of acute cerebral infarction,can improve the clinical symptoms,reduce the serum level of inflammatory factors,with good safety,which is worthy of clinical application.