蒲地蓝消炎口服液联合西帕依固龈液治疗牙龈炎的临床研究

Clinical study on Pudilan Xiaoyan Oral Liquid combined with Xipayi Guyin Mouth Rinse in treatment of gingivitis

目的探讨蒲地蓝消炎口服液联合西帕依固龈液治疗牙龈炎的临床疗效。方法选取2018年5月—2019年11月在河南大学赛思口腔医院接受治疗的108例牙龈炎患者当作研究对象,按照随机数字表法将全部患者分为对照组和治疗组,每组各54例。对照组含漱西帕依固龈液,3 mL/次,含漱3 min,5次/d。治疗组在对照组患者治疗的基础上口服蒲地蓝消炎口服液,10 mL/次,3次/d。两组患者均连续治疗2周。观察两组的临床疗效,比较两组的患者牙周指标菌斑指数(PLI)、龈沟出血指数(SBI)、牙龈指数(GI)、龈沟液中C反应蛋白(CRP)、前列腺素E2(PGE2)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平和疼痛程度。结果治疗后,治疗组患者的总有效率(92.59%)高于对照组(77.78%),差异具有统计学意义(P<0.05)。治疗后,两组的PLI、SBI、GI评分均低于治疗前,且治疗组PLI、SBI、GI评分低于对照组(P<0.05)。治疗后,两组的CRP、PGE2、IL-6、IL-1β水平明显低于治疗前(P<0.05);治疗后治疗组的CRP、PGE2、IL-6、IL-1β水平比对照组低(P<0.05)。治疗后,两组患者的VAS评分明显降低(P<0.05),且治疗组患者VAS评分较对照组降低的更明显(P<0.05)。结论蒲地蓝消炎口服液联合西帕依固龈液可有效提高牙龈炎的疗效,改善牙周症状,减轻牙周组织的炎症反应,降低疼痛程度,且安全性较好,具有重要临床研究价值。

Objective To investigate the clinical effect of Pudilan Xiaoyan Oral Liquid combined with Xipayi Guyin Mouth Rinse in treatment of gingivitis.Methods Patients(108 cases)with gingivitis in SATH Hospital of Stomatology Henan University from May 2018 to November 2019 were randomly divided into control and treatment groups,and each group had 54 cases.Patients in the control group were gargle administered with Xipayi Guyin Mouth Rinse,3 mL/time,gargle for 3 min,five times daily.Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group,10 mL/time,three times daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical efficacies were evaluated,and periodontal indexes(PLI,SBI,and GI)and the levels of inflammatory factor CRP,PGE2,IL-6 and IL-1βin two groups were compared.Results After treatment,the total effective rate in the treatment group(92.59%)was higher than that in the control group(77.78%),and the difference was statistically significant(P<0.05).After treatment,the scores of PLI,SBI,and GI in the two groups were significantly decreased(P<0.05),and the scores of PLI,SBI,and GI in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of CRP,PGE2,IL-6 and IL-1βin the two groups were significantly decreased(P<0.05),and the levels of inflammatory factors in the treatment group were lower than those in the control group(P<0.05).After treatment,VAS scores in the two groups was significantly decreased(P<0.05),and VAS scores in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion Pudilan Xiaoyan Oral Liquid combined with Xipayi Guyin Mouth Rinse has clinical curative effect in treatment of gingivitis,can improve the periodontal symptoms,reduce the inflammatory reaction of periodontal tissue,reduce the degree of pain,with good safety,which has important clinical research value.