脉络通颗粒联合尤瑞克林治疗脑梗死的临床研究

Clinical study on Mailuotong Granules combined with urinary kallidinogenase in treatment of cerebral infarction

目的探讨脉络通颗粒联合注射用尤瑞克林治疗脑梗死的临床疗效。方法选择2018年12月—2020年1月在郑州大学附属郑州中心医院进行治疗的126例脑梗死患者,根据数字表法随机分为对照组和治疗组,每组各63例。对照组患者静脉滴注注射用尤瑞克林,0.15 PNA溶于100 mL 0.9%氯化钠注射液中,1次/d。治疗组患者在对照组治疗基础上口服脉络通颗粒,6 g/次,3次/d。7 d为1个疗程,两组患者均连续治疗4个疗程。观察两组的临床疗效,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评定表(MBI)评分、脑血流量、脑血容量、血浆黏稠度、血清炎性因子水平。结果治疗后,治疗组总有效率96.83%,对照组为85.71%,治疗组显著高于对照组(P<0.05)。治疗后,两组患者的NIHSS评分显著降低,MBI评分显著升高(P<0.05),治疗组的改善程度显著优于对照组(P<0.05)。治疗后,两组患者脑血流量、脑血容量均显著提高,血浆黏稠度显著下降(P<0.05),治疗组脑血流量、脑血容量显著高于对照组,血浆黏稠度显著低于对照组(P<0.05)。治疗后,两组患者血清核转录因子-κB(NF-κB)、肿瘤坏死因子(TNF-α)、超敏C反应蛋白(hs-CRP)水平较治疗前均显著下降(P<0.05),治疗组NF-κB、TNF-α、hs-CRP水平下降程度显著大于对照组(P<0.05)。结论脉络通颗粒联合注射用尤瑞克林治疗脑梗死患者有较好的疗效,可有效改善患者神经功能、脑血流量、血浆黏稠度及血清中各项相关指标,促进患者日常活动能力恢复,具有一定临床使用价值。

Objective To explore the effects of Mailuotong Granules combined with Urinary Kallidinogenase for injection in treatment of cerebral infarction.Methods Patients(126 cases)with cerebral infarction in Zhengzhou Central Hospital Affiliated to Zhengzhou University from December 2018 to January 2020 were randomly divided into control and treatment groups,and each group had 63 cases.Patients in the control group were iv administered with Urinary Kallidinogenase for injection,0.15 PNA added into 0.9%sodium chloride injection 100 m L,once daily.Patients in the treatment group were po administered with Mailuotong Granules on the basis of the control group,6 g/time,three times daily.A course of treatment had 7 d,and patients in two groups were treated for 4 courses.After treatment,the clinical efficacies were evaluated,and NIHSS scores,MBI scores,cerebral blood volume flow,cerebral volume and plasma viscosity,and serum inflammatory factor levels in two groups were compared.Results After treatment,the total effective rate in the control and treatment groups was 96.83%and 85.71%,which was significantly higher in the treatment group than that in the control group(P<0.05).After treatment,NIHSS score in the two groups were significantly reduced,but MBI scores were significantly increased(P<0.05),and the improvement in the treatment group was significantly better than that in the control group(P<0.05).After treatment,the cerebral blood flow and cerebral blood volume in the two groups were significantly increased,but the plasma viscosity was significantly decreased(P<0.05).The cerebral blood flow and cerebral blood volume in the treatment group were significantly higher than those in the control group,but the plasma viscosity was significantly lower than that in the control group(P<0.05).After treatment,the levels of NF-κB,TNF-α,and hs-CRP in the two groups were significantly decreased(P<0.05),and the levels of NF-κB,TNF-α,and hs-CRP in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Mailuotong Granules combined with Urinary Kallidinogenase for injection has clinical curative effect in treatment of cerebral infarction,can effectively improve the patients’nerve function,cerebral blood flow,plasma viscosity and various related indexes in serum,and promote the recovery of patients’daily activity ability,which has a certain clinical value.