荣心丸联合曲美他嗪治疗急性病毒性心肌炎的临床研究

Clinical study on Rongxin Pills combined with trimetazidine in treatment of acute viral myocarditis

目的研究荣心丸联合盐酸曲美他嗪片治疗急性病毒性心肌炎的临床疗效。方法选取2018年10月—2019年10月在天津市蓟州区人民医院治疗的100例急性病毒性心肌炎患者作为研究对象,所有患者随机分为对照组和治疗组,每组各50例。对照组患者口服盐酸曲美他嗪片,1片/次,3次/d。治疗组在对照组治疗的基础上口服荣心丸,6丸/次,3次/d。两组患者接受治疗1个月。观察两组患者的临床疗效,并比较两组患者的心功能指标、心肌酶谱指标、抗氧化指标、血清炎性指标水平。结果治疗后,对照组和治疗组的总有效率分别为72.5%、94.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组左室舒张末内径(LVEED)、左室收缩末内径(LVESD)均明显降低,左心射血分数(LVEF)明显升高(P<0.05),且治疗组LVEED、LVESD明显低于对照组,LVEF明显高于对照组(P<0.05)。治疗后,两组患者肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)水平均显著降低(P<0.05);且治疗后治疗组CK-MB、cTnⅠ水平均明显低于对照组(P<0.05)。治疗后,两组血清SOD水平显著升高,MDA水平显著降低(P<0.05);且治疗组患者血清SOD水平明显高于对照组,血清MDA水平明显低于对照组(P<0.05)。治疗后,两组血清白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)水平均显著降低(P<0.05),且治疗组患者的血清炎性因子水平明显低于对照组(P<0.05)。结论荣心丸联合盐酸曲美他嗪片治疗急性病毒性心肌炎具有较好的临床疗效,能够改善患者心功能,降低炎性因子水平,值得在临床上推广应用。

Objective To study the efficacy of Rongxin Pills combined with Trimetazidine Hydrochloride Tablets in treatment of acute viral myocarditis.Methods Patients(100 cases)with acute viral myocarditis in People’s Hospital of Jizhou District of Tianjin from October 2018 to October 2019 were randomly divided into control and treatment groups,and each group had 50 cases.Patients in the control group were po administered with Trimetazidine Hydrochloride Tablets,1 tablet/time,three daily.Patients in the treatment group were po administered with Rongxin Pills on the basis of the control group,6 pills/time,three times daily.Patients in two groups were treated for 1 month.After treatment,the clinical efficacies were evaluated,and cardiac function index,myocardial enzyme spectrum index,antioxidant index,and serum level of inflammatory index in two groups were compared.Results After treatment,the clinical efficacies in the control and treatment groups were 72.5%and 94.00%,respectively,and there was difference between two groups(P<0.05).After treatment,the values of left ventricular end diastolic diameter(LVEED)and left ventricular end systolic diameter(LVESD)in the two groups were significantly reduced,while the values of left ventricular ejection fraction(LVEF)were significantly increased(P<0.05),but the values of LVEED and LVESD in the treatment group were significantly lower than those in the control group,but the values of LVEF in the treatment group were significantly higher than that in the control group(P<0.05).After treatment,the levels of creatine kinase isoenzyme(CK-MB)and cardiac troponin Ⅰ(cTnⅠ)in the two groups were significantly decreased(P<0.05).After treatment,the levels of CK-MB and cTnI in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the serum level of SOD in the two groups were significantly increased,but the serum level of MDA was significantly decreased(P<0.05).The serum level of SOD in the treatment group was significantly higher than that of the control group,but the serum level of MDA in the treatment was significantly lower than that of the control group(P<0.05).After treatment,the serum levels of interleukin(IL)-6,tumor necrosis factor(TNF)-α,and high sensitivity C reactive protein(hs-CRP)in the two groups were significantly lower(P<0.05),and the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Rongxin Pills combined with Trimetazidine Hydrochloride Tablets has clinical curative effect in treatment of acute viral myocarditis,can improve the heart function of patients and reduce the level of inflammatory factors,which is worthy of clinical application.