心脉隆注射液联合尼可地尔治疗老年低射血分数慢性心力衰竭的疗效观察

Clinical observation on Xinmailong Injection combined with nicorandil in treatment of elderly chronic heart failure with reduced ejection fraction

目的研究心脉隆注射液联合尼可地尔治疗老年低射血分数慢性心力衰竭(HFrEF)的临床效果。方法选取2016年2月—2018年2月新乡市第一人民医院低射血分数慢性心力衰竭患者124例,随机分为对照组和治疗组,每组各62例。对照组口服尼可地尔片,5 mg/次,3次/d。治疗组在对照组基础上给予心脉隆注射液,5 mg/kg加入生理盐水100 mL于皮试后静脉滴注,2次/d。两组均连续治疗14d。观察两组的临床疗效,比较两组治疗前后左室结构和功能指标、6min步行试验(6MWT)的变化情况。结果治疗后,对照组和治疗组总有效率分别是80.65%、93.55%,两组比较差异有统计学意义(P<0.05)。治疗后,两组左室舒张末期内径(LVEDD)和收缩末期内径(LVESD)均明显降低(P<0.05),而两组左室射血分数(LVEF)明显升高(P<0.05);且治疗后治疗组LVEDD和LVESD低于对照组,而LVEF高于对照组,两组比较差异有统计学意义(P<0.05)。结论心脉隆注射液联合尼可地尔治疗低射血分数慢性心力衰竭效果良好,可明显改善患者心功能和活动能力,具有一定的临床推广应用价值。

Objective To study the clinical effects of Xinmailong Injection combined with nicorandil in treatment of elderly chronic heart failure with reduced ejection fraction.Methods A total of 124 patients with chronic heart failure with reduced ejection fraction in Xinxiang First People’s Hospital from February 2016 to February 2018 were randomly divided into control group(n=62)and treatment group(n=62).The control group was po administered with Nicorandil Tablets,5 mg/time,three times daily.The treatment group was given Xinmailong Injection on the basis of the control group,5 mg/kg added into 100 mL normal saline to intravenous drip after skin test,5 mg/time,twice daily.All patients were treated for 14 days.The clinical efficacy were compared,the changes of left ventricular structure and functional indicators,6 min walking test(6 MWT)before and after treatment were compared between the two groups.Results The effective rates in control and treatment groups were 80.65%and 93.55%,respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,LVEDD and LVESD decreased significantly in both groups(P<0.05),while LVEF increased significantly in both groups(P<0.05).After treatment,LVEDD and LVESD in the treatment group were lower than those in the control group,while LVEF was higher than that in the control group.The difference between the two groups was statistically significant(P<0.05).Conclusion Xinmailong Injection combined with nicorandil has good effects in treatment of chronic heart failure with reduced ejection fraction,and it can significantly improve the heart function and activity ability,which has a certain clinical application value.