前列金丹片联合多沙唑嗪治疗良性前列腺增生的疗效观察

Clinical observation of Qianlie Jindan Tablets combined with doxazosin in treatiment of benign prostatic hyperplasia

目的分析前列金丹片联合多沙唑嗪片治疗良性前列腺增生的临床效果。方法选择2017年1月—2019年2月湖北省第三人民医院收治的良性前列腺增生患者133例,随机分成对照组(66例)和治疗组(67例)。对照组口服甲磺酸多沙唑嗪片,2mg/次,1次/d。治疗组在对照组治疗的基础上口服前列金丹片,6片/次,3次/d。两组患者均治疗3个月。观察两组患者临床疗效,同时比较治疗前后两组患者前列腺特异抗原(PSA)、前列腺素E2(PGE2)、最大尿流量(Qmax)、膀胱残余尿量(Ru)、国际前列腺症状评分(IPSS)和前列腺体积(PV)水平。结果治疗后,对照组临床有效率为78.79%,显著低于治疗组的92.54%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者PSA、PGE2水平显著降低(P<0.05),且治疗组患者PSA、PGE2水平明显比对照组低(P<0.05)。治疗后,两组患者Qmax水平显著升高(P<0.05),而Ru、IPSS和PV水平均显著降低(P<0.05),且治疗组患者这些指标改善效果明显优于对照组(P<0.05)。结论前列金丹片联合甲磺酸多沙唑嗪片治疗良性前列腺增生,可改善PSA、PGE2水平,提高最大尿流量,减小膀胱残余尿量和前列腺体积,具有较好的临床效果。

Objective To analyze the clinical effect of Qianlie Jindan Tablets combined with doxazosin in treatiment of benign prostatic hyperplasia.Methods Patients(133 cases)with benign prostatic hyperplasia in the Third People’s Hospital of Hubei Province from January 2017 to February 2019 were randomly divided into control(66 cases)and treatment(67 cases)groups.Patients in the control group were po administered with Doxazosin Mesylate Tablets,2 mg/time,once daily.Patients in the treatment group were po administered with Qianlie Jindan Tablets on the basis of the control group,6 tablets/time,three times daily.Patients in two groups were treated for 3 months.After treatment,the clinical efficacy was evaluated,and the levels of PSA,PGE2,Qmax,Ru,IPSS and PV in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control group was 78.79%,which was significantly lower than 92.54%in the treatment group,and there were differences between two groups(P<0.05).After treatment,the levels of PSA,PGE2 in two groups were significantly decreased(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the Qmax levels in two groups were significantly increased(P<0.05),but the Ru,IPSS and PV levels were significantly decreased(P<0.05),and these indexes in the treatment group were significantly better than those in the control group(P<0.05).Conclusion Qianlie Jindan Tablets combined with doxazosin in treatiment of benign prostatic hyperplasia can improve the levels of PSA and PGE2,increase the maximum urine flow,reduce the residual urine volume of bladder and prostate volume,and has good clinical effect.