蒺藜淫羊藿复合物缓解体力疲劳作用的研究

Study on the anti-fatigue effect of Thistle-Epimedium compound

目的研究以蒺藜提取物、淫羊藿提取物、西洋参提取物为主要原料的蒺藜淫羊藿复合物对缓解体力疲劳的作用。方法将160只ICR雄性小鼠分4组,每组40只动物,每组随机分为阴性对照组、蒺藜淫羊藿复合物低剂量[0.253 g/(kg·bw)]、中剂量[0.507 g/(kg·bw)]、高剂量[1.520 g/(kg·bw)]组。连续灌胃给药30 d后,测定小鼠负重游泳时间、游泳后血清尿素、血乳酸含量和肝糖原含量。结果与阴性对照组相比,蒺藜淫羊藿复合物高剂量组能显著延长负重小鼠的游泳时间(P<0.05),降低游泳后小鼠血乳酸含量(P<0.05),增加小鼠肝糖原含量(P<0.05),但不能显著减少小鼠血清尿素含量(P>0.05)。结论蒺藜淫羊藿复合物具有缓解体力疲劳的功效。

Objective To study the anti-fatigue effect of a Tribulus-Epimedium compound mainly made of Tribulus terrestris extract,Epimedium brevicornu extract and Panax quinquefolius extract.Methods Totally 160 male mice were divided into 4 groups,with 40 mice per group,and each group was randomly divided into the negative control group,low dosage[0.253 g/(kg·bw)] group,middle dosage[0.507 g/(kg·bw)] group and high dosage[1.520 g/(kg·bw)] group.After 30 d continuous gavage,indicators including the loaded swimming time,lactic acid content in the whole blood,urea nitrogen in the serum and hepatic glycogen content were determined.Results Compared to the negative control group,high dosage group of Tribulus-Epimedium compound could significantly prolonged the loaded swimming time(P<0.05),decreased the content of the lactic acid(P<0.05) and increased the content of hepatic glycogen(P<0.05),but the urea nitrogen in the whole blood was not significantly decreased(P>0.05).Conclusion It is suggested that Thistle-Epimedium compound could alleviate physical fatigue in mice.