非酒精性脂肪性胰腺病与乳腺癌化疗的相关性

Correlation between Non-alcohol Fatty Pancreas Disease and Breast Cancer with Chemotherapy

目的分析非酒精性脂肪性胰腺病(NAFPD)与乳腺癌化疗的相关性.方法选择2017年1月至2018年12月在医院乳腺外科化疗的乳腺癌患者330例,比较乳腺癌患者化疗前后的体质量指数(BMI)、腹围、收缩压、舒张压及生化指标(三酰甘油、高密度脂蛋白、血糖)水平;比较乳腺癌患者化疗前后的NAFPD和代谢综合征检出情况;比较检出NAFPD与未检出NAFPD乳腺癌患者化疗前后的BMI、腹围、收缩压、舒张压及三酰甘油、高密度脂蛋白、血糖水平;比较检出NAFPD与未检出NAFPD乳腺癌患者化疗前后的代谢综合征检出情况.结果化疗前后,乳腺癌患者的BMI、腹围、收缩压、三酰甘油、高密度脂蛋白比较,差异均有统计学意义(P<0.05);化疗前后,乳腺癌患者的舒张压及血糖比较,差异均无统计学意义(P>0.05).化疗前后,乳腺癌患者的NAFPD和代谢综合征检出率比较,差异均有统计学意义(P<0.05).化疗前,未检出与检出NAFPD乳腺癌患者的BMI、收缩压、舒张压、三酰甘油、高密度脂蛋白、血糖比较,差异均有统计学意义(P<0.05);化疗后,未检出与检出NAFPD乳腺癌患者的BMI、腹围、收缩压、舒张压、三酰甘油、高密度脂蛋白、血糖比较,差异均有统计学意义(P<0.05);化疗前,未检出与检出NAFPD乳腺癌患者的腹围比较,差异无统计学意义(P>0.05).化疗前后,未检出与检出NAFPD乳腺癌患者的代谢综合征检出率比较,差异均有统计学意义(P<0.05).结论NAFPD在乳腺癌患者中的检出率较高,且化疗后该病的检出率高于化疗前,化疗后乳腺癌患者的血脂、血糖、血压和BMI均有所增高.

Objective To analyze the correlation between non-alcohol fatty pancreas disease(NAFPD)and breast cancer with chemotherapy.Methods 330 cases of breast cancer patients who underwent chemotherapy in department of breast surgery in our hospital from January 2017 to December 2018 were selected.The body mass index(BMI),abdominal circumference,systolic blood pressure,diastolic blood pressure and biochemical indicators(triacylglycerol,highdensity lipoprotein,blood glucose)were compared before and after chemotherapy of the breast cancer patients,the detection rate of NAFPD and metabolic syndrome in breast cancer patients were compared before and after chemotherapy.The BMI,abdominal circumference,systolic blood pressure,diastolic blood pressure,triacylglycerol,high-density lipoprotein,blood glucose were compared between NAFPD and non-NAFPD patients before and after chemotherapy.The detection rate of metabolic syndrome was compared between NAFPD and non-NAFPD patients before and after chemotherapy.Results The differences of BMI,abdominal circumference,systolic blood pressure,triacylglycerol,and high-density lipoprotein of breast cancer patients were statistically significant before and after chemotherapy(P<0.05),but there was no statistically significant difference in diastolic blood pressure and blood glucose before and after chemotherapy(P>0.05).The detection rate of NAFPD and metabolic syndrome in breast cancer patients were statistically significant before and after chemotherapy(P<0.05).Before chemotherapy,there were statistically significant differences in BMI,systolic blood pressure,diastolic blood pressure,triacylglycerol,high-density lipoprotein,and blood glucose between NAFPD patients and non-NAFPD patients(P<0.05),but there was no statistically significant difference in abdominal circumference between NAFPD patients and non-NAFPD patients(P>0.05);after chemotherapy,there were statistically significant differences in BMI,abdominal circumference,systolic blood pressure,diastolic blood pressure,triacylglycerol,high-density lipoprotein,and blood glucose between NAFPD patients and non-NAFPD patients(P<0.05).Before and after chemotherapy,the the detection rate of NAFPD and metabolic syndrome between NAFPD patients and non-NAFPD patients were statistically significant(P<0.05).Conclusion Breast cancer patients have a higher detection rate of NAFPD,and detection rate of NAFPD after chemotherapy is higher than before chemotherapy.After chemotherapy,the blood lipids,blood glucose,blood pressure and BMI of breast cancer patients will increase.